About the Authors

Melissa K. Boles

Contributed equally to this work with: Melissa K. Boles, Bonney M. Wilkinson

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Bonney M. Wilkinson

Contributed equally to this work with: Melissa K. Boles, Bonney M. Wilkinson

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Laurens G. Wilming

Affiliation The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

Bin Liu

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Frank J. Probst

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Jennifer Harrow

Affiliation The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

Darren Grafham

Affiliation The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

Kathryn E. Hentges

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Lanette P. Woodward

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Andrea Maxwell

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Karen Mitchell

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Michael D. Risley

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Randy Johnson

Affiliation The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Karen Hirschi

Affiliation Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America

James R. Lupski

Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America, Texas Children's Hospital, Houston, Texas, United States of America

Yosuke Funato

Affiliation Laboratory of Intracellular Signaling, Institute for Protein Research, Osaka University, Osaka, Japan

Hiroaki Miki

Affiliation Laboratory of Intracellular Signaling, Institute for Protein Research, Osaka University, Osaka, Japan

Pablo Marin-Garcia

Affiliation The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

Lucy Matthews

Affiliation The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

Alison J. Coffey

Affiliation The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

Anne Parker

Affiliation The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

Tim J. Hubbard

Affiliation The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

Jane Rogers

Affiliation The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

Allan Bradley

Affiliation The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

David J. Adams

mjustice@bcm.edu (MJJ);da1@sanger.ac.uk (DJA)

Affiliation The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

Monica J. Justice

mjustice@bcm.edu (MJJ);da1@sanger.ac.uk (DJA)

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JR AB DJA MJJ. Performed the experiments: MKB BMW LGW JH DG LPW AM KM MDR PMG LM AJC AP TJH JR. Analyzed the data: MKB BMW LGW BL LPW AM DJA MJJ. Contributed reagents/materials/analysis tools: BL KEH RJ KH YF HM AB DJA MJJ. Wrote the paper: MKB BMW FJP KEH JRL AB DJA MJJ.