About the Authors
- Sara Hägg
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Contributed equally to this work with: Sara Hägg, Josefin Skogsberg, Jesper Lundström
Affiliations The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Department of Computational Biology, Linköping Institute of Technology, Linköping University, Linköping, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden
- Josefin Skogsberg
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Contributed equally to this work with: Sara Hägg, Josefin Skogsberg, Jesper Lundström
Affiliations The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden
- Jesper Lundström
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Contributed equally to this work with: Sara Hägg, Josefin Skogsberg, Jesper Lundström
Affiliations The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Department of Computational Biology, Linköping Institute of Technology, Linköping University, Linköping, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden
- Peri Noori
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Affiliations The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden
- Roland Nilsson
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Affiliations Department of Computational Biology, Linköping Institute of Technology, Linköping University, Linköping, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden
- Hua Zhong
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Affiliation Rosetta Inpharmatics, Merck, Seattle, Washington, United States of America
- Shohreh Maleki
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Affiliation The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
- Ming-Mei Shang
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Affiliations The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden
- Björn Brinne
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Affiliation Department of Computational Biology, Linköping Institute of Technology, Linköping University, Linköping, Sweden
- Maria Bradshaw
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Affiliations The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Department of Computational Biology, Linköping Institute of Technology, Linköping University, Linköping, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden
- Vladimir B. Bajic
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Affiliations South African National Bioinformatics Institute (SANBI), University of the Western Cape, Cape Town, South Africa, Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia
- Ann Samnegård
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Affiliation Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
- Angela Silveira
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Affiliation Cardiovascular Genetics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
- Lee M. Kaplan
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Affiliation Massachusetts General Hospital (MGH) Weight Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
- Bruna Gigante
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Affiliation Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- Karin Leander
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Affiliation Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- Ulf de Faire
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Affiliation Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- Stefan Rosfors
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Affiliation Department of Clinical Physiology, Stockholm Söder Hospital, Karolinska Institutet, Stockholm, Sweden
- Ulf Lockowandt
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Affiliations Department of Thoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
- Jan Liska
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Affiliations Department of Thoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
- Peter Konrad
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Affiliation Department of Surgery, Stockholm Söder Hospital, Karolinska Institutet, Stockholm, Sweden
- Rabbe Takolander
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Affiliation Department of Surgery, Stockholm Söder Hospital, Karolinska Institutet, Stockholm, Sweden
- Anders Franco-Cereceda
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Affiliations Department of Thoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
- Eric E. Schadt
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Affiliation Rosetta Inpharmatics, Merck, Seattle, Washington, United States of America
- Torbjörn Ivert
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Affiliations Department of Thoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
- Anders Hamsten
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Affiliation Cardiovascular Genetics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
- Jesper Tegnér
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Affiliations The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Department of Computational Biology, Linköping Institute of Technology, Linköping University, Linköping, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden
- Johan Björkegren
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* E-mail: johan.bjorkegren@ki.se
Affiliations The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Department of Computational Biology, Linköping Institute of Technology, Linköping University, Linköping, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden
Competing Interests
Clinical Gene Networks AB with Johan Björkegren and Jesper Tegnér as major shareholders has filed a PCT application for a screening method using genes in the atherosclerosis module including LDB2 (PCT/SE2007/00864).
Author Contributions
Conceived and designed the experiments: S Hägg, J Skogsberg, J Lundström, H Zhong, VB Bajic, LM Kaplan, U de Faire, S Rostors, EE Schadt, T Ivert, J Tegnér, J Björkegren. Performed the experiments: S Hägg, J Skogsberg, J Lundström, P Noori, R Nilsson, H Zhong, S Maleki, MM Shang, M Bradshaw, VB Bajic, A Silveria, B Gigante, K Leander, S Rosfors, U Lockowandt, J Liska, P Konrad, R Takolander, A Franco-Cereceda, EE Schadt, T Ivert, J Björkegren. Analyzed the data: S Hägg, J Skogsberg, J Lundström, R Nilsson, H Zhong, B Brinne, VB Bajic, S Rosfors, EE Schadt, J Tegnér, J Björkegren. Contributed reagents/materials/analysis tools: J Lundström, A Samnegård, LM Kaplan, U der Faire, P Konrad, R Takolander, A Franco-Cereceda, EE Schadt, T Ivert, A Hamsten, J Tegnér, J Björkegren. Wrote the paper: S Hägg, J Skogsberg, J Lundström, H Zhong, EE Schadt, T Ivert, A Hamsten, J Tegnér, J Björkegren.