About the Authors

Sara Hägg

Contributed equally to this work with: Sara Hägg, Josefin Skogsberg, Jesper Lundström

Affiliations The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Department of Computational Biology, Linköping Institute of Technology, Linköping University, Linköping, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden

Josefin Skogsberg

Contributed equally to this work with: Sara Hägg, Josefin Skogsberg, Jesper Lundström

Affiliations The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden

Jesper Lundström

Contributed equally to this work with: Sara Hägg, Josefin Skogsberg, Jesper Lundström

Affiliations The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Department of Computational Biology, Linköping Institute of Technology, Linköping University, Linköping, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden

Peri Noori

Affiliations The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden

Roland Nilsson

Affiliations Department of Computational Biology, Linköping Institute of Technology, Linköping University, Linköping, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden

Hua Zhong

Affiliation Rosetta Inpharmatics, Merck, Seattle, Washington, United States of America

Shohreh Maleki

Affiliation The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

Ming-Mei Shang

Affiliations The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden

Björn Brinne

Affiliation Department of Computational Biology, Linköping Institute of Technology, Linköping University, Linköping, Sweden

Maria Bradshaw

Affiliations The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Department of Computational Biology, Linköping Institute of Technology, Linköping University, Linköping, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden

Vladimir B. Bajic

Affiliations South African National Bioinformatics Institute (SANBI), University of the Western Cape, Cape Town, South Africa, Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia

Ann Samnegård

Affiliation Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden

Angela Silveira

Affiliation Cardiovascular Genetics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

Lee M. Kaplan

Affiliation Massachusetts General Hospital (MGH) Weight Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Bruna Gigante

Affiliation Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Karin Leander

Affiliation Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Ulf de Faire

Affiliation Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Stefan Rosfors

Affiliation Department of Clinical Physiology, Stockholm Söder Hospital, Karolinska Institutet, Stockholm, Sweden

Ulf Lockowandt

Affiliations Department of Thoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

Jan Liska

Affiliations Department of Thoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

Peter Konrad

Affiliation Department of Surgery, Stockholm Söder Hospital, Karolinska Institutet, Stockholm, Sweden

Rabbe Takolander

Affiliation Department of Surgery, Stockholm Söder Hospital, Karolinska Institutet, Stockholm, Sweden

Anders Franco-Cereceda

Affiliations Department of Thoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

Eric E. Schadt

Affiliation Rosetta Inpharmatics, Merck, Seattle, Washington, United States of America

Torbjörn Ivert

Affiliations Department of Thoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

Anders Hamsten

Affiliation Cardiovascular Genetics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

Jesper Tegnér

Affiliations The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Department of Computational Biology, Linköping Institute of Technology, Linköping University, Linköping, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden

Johan Björkegren

johan.bjorkegren@ki.se

Affiliations The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Department of Computational Biology, Linköping Institute of Technology, Linköping University, Linköping, Sweden, Clinical Gene Networks AB, Karolinska Science Park, Stockholm, Sweden

Competing Interests

Clinical Gene Networks AB with Johan Björkegren and Jesper Tegnér as major shareholders has filed a PCT application for a screening method using genes in the atherosclerosis module including LDB2 (PCT/SE2007/00864).

Author Contributions

Conceived and designed the experiments: S Hägg, J Skogsberg, J Lundström, H Zhong, VB Bajic, LM Kaplan, U de Faire, S Rostors, EE Schadt, T Ivert, J Tegnér, J Björkegren. Performed the experiments: S Hägg, J Skogsberg, J Lundström, P Noori, R Nilsson, H Zhong, S Maleki, MM Shang, M Bradshaw, VB Bajic, A Silveria, B Gigante, K Leander, S Rosfors, U Lockowandt, J Liska, P Konrad, R Takolander, A Franco-Cereceda, EE Schadt, T Ivert, J Björkegren. Analyzed the data: S Hägg, J Skogsberg, J Lundström, R Nilsson, H Zhong, B Brinne, VB Bajic, S Rosfors, EE Schadt, J Tegnér, J Björkegren. Contributed reagents/materials/analysis tools: J Lundström, A Samnegård, LM Kaplan, U der Faire, P Konrad, R Takolander, A Franco-Cereceda, EE Schadt, T Ivert, A Hamsten, J Tegnér, J Björkegren. Wrote the paper: S Hägg, J Skogsberg, J Lundström, H Zhong, EE Schadt, T Ivert, A Hamsten, J Tegnér, J Björkegren.