About the Authors

M. Helen Rajpar

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

Ben McDermott

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

Louise Kung

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

Rachel Eardley

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

Lynette Knowles

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

Mel Heeran

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

David J. Thornton

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

Richard Wilson

Affiliation Musculoskeletal Disorders Theme, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia

John F. Bateman

Affiliation Musculoskeletal Disorders Theme, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia

Richard Poulsom

Affiliation Histopathology Unit, Cancer Research UK, London Research Institute, London, United Kingdom

Peter Arvan

Affiliation Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

Karl E. Kadler

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

Michael D. Briggs

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

Raymond P. Boot-Handford

ray.boot-handford@manchester.ac.uk

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DJT KEK MDB RPBH. Performed the experiments: MHR BM LK RE RW JFB. Analyzed the data: MHR BM LK DJT JFB RP KEK MDB RPBH. Contributed reagents/materials/analysis tools: LK MH JFB RP PA. Wrote the paper: MHR DJT RW JFB MDB RPBH.