About the Authors

Melanie Kolz, Eva Albrecht, Claudia Lamina, Rui Wang-Sattler, Angela Doering, H.-Erich Wichmann, Thomas Illig, Christian Gieger
Institute of Epidemiology, Helmholtz Zentrum München, National Research Center for Environment and Health, Neuherberg, Germany

Toby Johnson, Jacques S. Beckmann, Sven Bergmann
Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland

Toby Johnson, Sven Bergmann
Swiss Institute of Bioinformatics, Lausanne, Switzerland

Toby Johnson, Murielle Bochud
University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland

Serena Sanna, Manuela Uda
Istituto di Neurogenetica e Neurofarmacologia, Cagliari, Italy

Alexander Teumer, Georg Homuth, Uwe Völker
Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany

Veronique Vitart, Alan F. Wright
MRC Human Genetics Unit, IGMM, Western General Hospital, Crewe Road, Edinburgh, United Kingdom

Markus Perola, Perttu Salo, Veikko Salomaa
Department of Chronic Disease Prevention, Institute of Health and Welfare, Helsinki, Finland

Markus Perola, Perttu Salo, Leena Peltonen
FIMM, Institute of Molecular Medicine, Helsinki, Finland

Massimo Mangino, Tim D. Spector
DTR Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

Chris Wallace
The Diabetes Inflammation Laboratory, Cambridge Institute of Medical Research, Cambridge University, Cambridge, United Kingdom

Martin Farrall, John Peden, Hugh Watkins
Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom

Martin Farrall, Mark I. McCarthy, John Peden, Hugh Watkins
The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Åsa Johansson, Ulf Gyllensten
Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

Dale R. Nyholt, John B. Whitfield
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia

Yurii Aulchenko
Department of Epidemiology, Erasmus MC Rotterdam, Rotterdam, The Netherlands

Jacques S. Beckmann
Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

Morris Brown
Clinical Pharmacology Unit, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom

Harry Campbell, James F. Wilson, Igor Rudan
Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom

John Connell, Anna Dominiczak
Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

Claudia Lamina
Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria

Mark I. McCarthy
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom

Mark I. McCarthy
National Institute for Health Research, Oxford Biomedical Research Centre, University of Oxford, Headington, Oxford, United Kingdom

Thomas Meitinger, Holger Prokisch
Institute of Human Genetics, Helmholtz Zentrum München, National Research Center for Environment and Health, Neuherberg, Germany

Vincent Mooser, Dawn Waterworth
Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America

Patricia Munroe, Mark Caulfield
The William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, England

Matthias Nauck
Institut für Klinische Chemie und Laboratoriumsmedizin, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany

Nilesh J. Samani
Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom

David Schlessinger, Ramaiah Nagaraja
Laboratory of Genetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Gérard Waeber, Peter Vollenweider
Department of Medicine and Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

Jerzy Adamski
Genome Analysis Centre, Institute for Experimental Genetics, Helmholtz Zentrum München, National Research Center for Environment and Health, Neuherberg, Germany

Igor Rudan
Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia

Igor Rudan
Gen-Info, Zagreb, Croatia

Peter Pramstaller
Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy

Peter Pramstaller
Affiliated Institute of the University Lübeck, Department of Neurology, Central Hospital, Bolzano, Italy

H.-Erich Wichmann
IBE, Chair of Epidemiology, University of Munich, Germany

Leena Peltonen
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

Henry Völzke
Institute for Community Medicine, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany

Corresponding Author

christian.gieger@helmholtz-muenchen.de

Competing Interests

Vincent Mooser and Dawn Waterworth are full-time employees of GlaxoSmithKline, a pharmaceutical company. Peter Vollenweider and Gerard Waeber received financial support from GlaxoSmithKline to build the CoLaus study.

Author Contributions

Conceived and designed the experiments: AFW JA JBW UG JFW IR PP HW AD HEW TDS LP HV RN PV MC TI CG. Performed the experiments: HP RWS. Analyzed the data: MK TJ SS AT VV MP MM EA CW MF ÅJ DRN YA CL PS RWS CG. Contributed reagents/materials/analysis tools: JSB SB MB MB HC JC AD GH MIM TM VM PM MN JP VS NJS DS MU UV GW DW TI. Wrote the paper: MK TJ CG. Conducted meta-analysis: MK TJ EA CG.