About the Authors

David C. Hess

Affiliation Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

Chad L. Myers

Contributed equally to this work with: Chad L. Myers, Curtis Huttenhower, Matthew A. Hibbs

Affiliations Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America, Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America, Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America

Curtis Huttenhower

Contributed equally to this work with: Chad L. Myers, Curtis Huttenhower, Matthew A. Hibbs

Affiliations Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America, Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America

Matthew A. Hibbs

Contributed equally to this work with: Chad L. Myers, Curtis Huttenhower, Matthew A. Hibbs

Affiliations Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America, Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America

Alicia P. Hayes

Affiliation Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

Jadine Paw

Affiliation Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

John J. Clore

Affiliation Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

Rosa M. Mendoza

Affiliation Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

Bryan San Luis

Affiliation Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

Corey Nislow

Affiliation Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

Guri Giaever

Affiliation Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

Michael Costanzo

Affiliation Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

Olga G. Troyanskaya

ogt@cs.princeton.edu (OGT); acaudy@princeton.edu (AAC)

Affiliations Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America, Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America

Amy A. Caudy

ogt@cs.princeton.edu (OGT); acaudy@princeton.edu (AAC)

Affiliation Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DCH CLM CH MAH CN GG MC OGT AAC. Performed the experiments: DCH APH JP JJC RMM BSL MC AAC. Analyzed the data: DCH CLM CH MAH JJC AAC. Contributed reagents/materials/analysis tools: MC OGT AAC. Wrote the paper: DCH CLM CH MAH OGT AAC.