About the Authors

Edwin Choy

Contributed equally to this work with: Edwin Choy, Roman Yelensky

Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Roman Yelensky

Contributed equally to this work with: Edwin Choy, Roman Yelensky

Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard–MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America

Sasha Bonakdar

Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Robert M. Plenge

Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Richa Saxena

Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Philip L. De Jager

Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Harvard Medical School–Partners Healthcare Center for Genetics and Genomics, Boston, Massachusetts, United States of America

Stanley Y. Shaw

Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Systems Biology and Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Cara S. Wolfish

Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Jacqueline M. Slavik

Affiliations Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Biomedical Research Institute, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Chris Cotsapas

Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Manuel Rivas

Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United Sates of America

Emmanouil T. Dermitzakis

Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom

Ellen Cahir-McFarland

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Channing Laboratory and Infectious Disease Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Elliott Kieff

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Channing Laboratory and Infectious Disease Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

David Hafler

Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Mark J. Daly

Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

David Altshuler

altshuler@molbio.mgh.harvard.edu

Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EC RY SB SYS ECM EK DH MJD DA. Performed the experiments: EC SB RMP RS PLDJ CSW JMS. Analyzed the data: EC RY MJD DA. Contributed reagents/materials/analysis tools: RY CC MR ETD. Wrote the paper: EC RY MJD DA. Jointly supervised the project: MJD DA.