About the Authors

Randell T. Libby

Contributed equally to this work with: Randell T. Libby, Katharine A. Hagerman

Affiliation Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, United States of America

Katharine A. Hagerman

Contributed equally to this work with: Randell T. Libby, Katharine A. Hagerman

Affiliations Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

Victor V. Pineda

Affiliation Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, United States of America

Rachel Lau

Affiliation Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

Diane H. Cho

Affiliation Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Sandy L. Baccam

Affiliation Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, United States of America

Michelle M. Axford

Affiliations Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

John D. Cleary

Affiliations Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

James M. Moore

Affiliation Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Bryce L. Sopher

Affiliation Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, United States of America

Stephen J. Tapscott

Affiliations Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Neurology (Neurogenetics), University of Washington Medical Center, Seattle, Washington, United States of America

Galina N. Filippova

Affiliation Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Christopher E. Pearson

Affiliations Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

Albert R. La Spada

laspada@u.washington.edu

Affiliations Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, United States of America, Department of Neurology (Neurogenetics), University of Washington Medical Center, Seattle, Washington, United States of America, Department of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, Washington, United States of America, Center for Neurogenetics & Neurotherapeutics, University of Washington Medical Center, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RTL KAH VVP SJT GNF CEP ARLS. Performed the experiments: RTL KAH VVP RL DHC SLB MMA JMM BLS. Analyzed the data: RTL KAH VVP RL DHC SLB MMA JDC CEP ARLS. Contributed reagents/materials/analysis tools: SJT GNF. Wrote the paper: RTL KAH JDC GNF CEP ARLS.