About the Authors

Manching Ku

Contributed equally to this work with: Manching Ku, Richard P. Koche, Esther Rheinbay

Affiliations Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Richard P. Koche

Contributed equally to this work with: Manching Ku, Richard P. Koche, Esther Rheinbay

Affiliations Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Division of Health Sciences and Technology, MIT, Cambridge, Massachusetts, United States of America

Esther Rheinbay

Contributed equally to this work with: Manching Ku, Richard P. Koche, Esther Rheinbay

Affiliations Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Bioinformatics Program and Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Eric M. Mendenhall

Affiliations Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Mitsuhiro Endoh

Affiliation RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Japan

Tarjei S. Mikkelsen

Affiliations Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Division of Health Sciences and Technology, MIT, Cambridge, Massachusetts, United States of America

Aviva Presser

Affiliations Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America

Chad Nusbaum

Affiliation Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Xiaohui Xie

Affiliation Department of Computer Science, University of California Irvine, Irvine, California, United States of America

Andrew S. Chi

Affiliations Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Mazhar Adli

Affiliations Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Simon Kasif

Affiliation Bioinformatics Program and Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Leon M. Ptaszek

Affiliations Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America, Stowers Medical Institute, Center for Regenerative Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Chad A. Cowan

Affiliations Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America, Stowers Medical Institute, Center for Regenerative Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Eric S. Lander

Affiliations Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Whitehead Institute for Biomedical Research, MIT, Cambridge, Massachusetts, United States of America

Haruhiko Koseki

Affiliation RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Japan

Bradley E. Bernstein

Bernstein.Bradley@mgh.harvard.edu

Affiliations Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BEB. Performed the experiments: MK RPK ER ME MA. Analyzed the data: MK RPK ER EMM TSM AP XX BEB. Contributed reagents/materials/analysis tools: ME TSM CN ASC SK LMP CAC ESL HK. Wrote the paper: MK RPK ER BEB.