Screening and Replication using the Same Data Set: Testing Strategies for Family-Based Studies in which All Probands Are Affected

Amy Murphy; Scott T. Weiss; Christoph Lange

doi:10.1371/journal.pgen.1000197

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Peer-reviewed

Research Article

Screening and Replication using the Same Data Set: Testing Strategies for Family-Based Studies in which All Probands Are Affected

Amy Murphy,

Affiliations Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Genomic Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
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Scott T. Weiss,

Affiliations Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Genomic Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
⨯
Christoph Lange

* E-mail: clange@hsph.harvard.edu

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Center for Genomic Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯

Screening and Replication using the Same Data Set: Testing Strategies for Family-Based Studies in which All Probands Are Affected

Amy Murphy,
Scott T. Weiss,
Christoph Lange

Published: September 19, 2008
https://doi.org/10.1371/journal.pgen.1000197

About the Authors

Amy Murphy

Affiliations Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Genomic Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Scott T. Weiss

Christoph Lange

* E-mail: clange@hsph.harvard.edu

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Center for Genomic Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AM STW CL. Performed the experiments: AM. Analyzed the data: AM. Contributed reagents/materials/analysis tools: STW. Wrote the paper: AM CL.

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Single nucleotide polymorphisms
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