About the Authors

Malene Hansen

¤ Current address: Burnham Institute for Medical Research, La Jolla, California, United States of America

Affiliation Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

Abha Chandra

Affiliation Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America

Laura L Mitic

Affiliation Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

Brian Onken

Affiliation Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America

Monica Driscoll

Affiliation Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America

Cynthia Kenyon

To whom correspondence should be addressed. E-mail: ckenyon@biochem.ucsf.edu

Affiliation Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AC carried out the experiments involving dietary restriction of wild-type worms in liquid media as well as the spectrophotometric analysis involving bec-1 RNAi treatments. LLM created the strains CF1850, 1908, and 2946 and assisted in the lifespan analysis of CF2846. BO carried out the spectrophotometric analysis involving rab-10 RNAi treatments and assisted in the experiments involving dietary restriction of wild-type worms in liquid media. MH carried out all of the other experiments. MH and CK designed the experiments and wrote the paper.