About the Authors

Ismael Al-Ramahi

Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America , Departamento de Biología, Facultad de Ciencias-University Autonoma de Madrid, Madrid, Spain

Alma M Pérez

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Janghoo Lim

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Minghang Zhang

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Rie Sorensen

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Maria de Haro

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Joana Branco

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Stefan M Pulst

Affiliation Division of Neurology, Cedars-Sinai Medical Center; Departments of Medicine and Neurobiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America

Huda Y Zoghbi

Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America , Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America , Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America

Juan Botas

To whom correspondence should be addressed. E-mail: jbotas@bcm.tmc.edu

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

I. Al-Ramahi, J. Lim, S. M. Pulst, H. Y. Zoghbi, and J. Botas conceived and designed the experiments. I. Al-Ramahi, A. M. Pérez, J. Lim, M. Zhang, R. Sorensen, and J. Branco performed the experiments. I. Al-Ramahi, A. M. Pérez, J. Lim, S. M. Pulst, H. Y. Zoghbi, and J. Botas analyzed the data. M. de Haro, S. M. Pulst, and H. Y. Zoghbi contributed reagents/materials/analysis tools. I. Al-Ramahi and J. Botas wrote the paper.