About the Authors

Sreeram V Ramagopalan

Contributed equally to this work with: Sreeram V Ramagopalan, Andrew P Morris, David A Dyment

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom , Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom

Andrew P Morris

Contributed equally to this work with: Sreeram V Ramagopalan, Andrew P Morris, David A Dyment

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

David A Dyment

Contributed equally to this work with: Sreeram V Ramagopalan, Andrew P Morris, David A Dyment

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom , Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom

Blanca M Herrera

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom , Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom

Gabriele C DeLuca

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom , Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom

Matthew R Lincoln

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom , Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom

Sarah M Orton

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom , Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom

Michael J Chao

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom , Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom

A. Dessa Sadovnick

Affiliation Department of Medical Genetics and Faculty of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada

George C Ebers

To whom correspondence should be addressed. E-mail: george.ebers@clneuro.ox.ac.uk

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom , Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

GCE conceived and designed the experiments. SVR, DAD, BMH, GCD, MRL, SMO, and MJC performed the experiments. SVR, APM, and DAD analyzed the data. SVR and DAD wrote the paper.