About the Authors

Jong-Min Lee

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Elena V Ivanova

Address ¤ Current address: Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Ihn Sik Seong

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Tanya Cashorali

Affiliation Children's Hospital Informatics Program, Children's Hospital, Boston, Massachusetts, United States of America

Isaac Kohane

Affiliation Children's Hospital Informatics Program, Children's Hospital, Boston, Massachusetts, United States of America

James F Gusella

Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America , Huntington's Disease Society of America Coalition for the Cure Mitochondria and Energy Metabolism Team, New York, New York, United States of America

Marcy E MacDonald

To whom correspondence should be addressed. E-mail: macdonam@helix.mgh.harvard.edu

Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America , Huntington's Disease Society of America Coalition for the Cure Mitochondria and Energy Metabolism Team, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JML, EVI, JFG, and MEM conceived and designed the experiments. JML, EVI, and ISS performed the experiments. JML, EVI, ISS, TC, IK, and MEM analyzed the data. JML and MEM wrote the paper, incorporating comments from EVI, ISS, TC, IK, and JFG. IK, JFG, and MEM obtained the funding to support the work.