About the Authors

Angelo Scuteri

Contributed equally to this work with: Angelo Scuteri, Serena Sanna

Affiliations Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy , Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

Serena Sanna

Contributed equally to this work with: Angelo Scuteri, Serena Sanna

Affiliations Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America , Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

Wei-Min Chen

Affiliation Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

Manuela Uda

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

Giuseppe Albai

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

James Strait

Affiliation Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

Samer Najjar

Affiliation Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

Ramaiah Nagaraja

Affiliation Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

Marco Orrú

Affiliations Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy , Unità Operativa Semplice Cardiologia, Divisione di Medicina, Presidio Ospedaliero Santa Barbara, Iglesias, Italy

Gianluca Usala

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

Mariano Dei

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

Sandra Lai

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

Andrea Maschio

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

Fabio Busonero

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

Antonella Mulas

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

Georg B Ehret

Affiliation Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Ashley A Fink

Affiliation Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Alan B Weder

Affiliation Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America

Richard S Cooper

Affiliation Department of Preventive Medicine and Epidemiology, Loyola Stritch School of Medicine, Chicago, Illinois, United States of America

Pilar Galan

Affiliations Institut Scientifique et Technique de la Nutrition et de l'Alimentation, Paris, France , INSERM, U557 (UMR INSERM/INRA/CNAM), Paris, France

Aravinda Chakravarti

Affiliation Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

David Schlessinger

To whom correspondence should be addressed. E-mail: schlessingerd@grc.nia.nih.gov (DS); goncalo@umich.edu (GRA)

Affiliation Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

Antonio Cao

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

Edward Lakatta

Affiliation Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

Gonçalo R Abecasis

To whom correspondence should be addressed. E-mail: schlessingerd@grc.nia.nih.gov (DS); goncalo@umich.edu (GRA)

Affiliation Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

S. Najjar, G. B. Ehret, A. Chakravarti, D. Schlessinger, A. Cao, E. Lakatta, and G. R. Abecasis conceived and designed the experiments. M. Uda, G. Albai, M. Orrú, G. Usala, M. Dei, S. Lai, A. Maschio, F. Busonero, A. Mulas, G. B. Ehret, and A. A. Fink performed the experiments. S. Sanna, W.-M. Chen and G. Albai analyzed the data. S. Najjar, R. Nagaraja, A. B. Weder, R. S. Cooper, P. Galan, and A. Cao contributed reagents/materials/analysis tools. A. Scuteri, S. Sanna, J. Strait, D. Schlessinger, E. Lakatta, and G. R. Abecasis wrote the paper.