About the Authors

Joyce van de Leemput

Contributed equally to this work with: Joyce van de Leemput, Jayanth Chandran

Affiliations Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America , Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London, United Kingdom

Jayanth Chandran

Contributed equally to this work with: Joyce van de Leemput, Jayanth Chandran

Affiliations Transgenics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America , Department of Biology, Johns Hopkins University, Baltimore, Maryland, United States of America

Melanie A Knight

Affiliation Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

Lynne A Holtzclaw

Affiliation Section on Cell Biology and Signal Transduction, National Institute on Child Health and Development, National Institutes of Health, Bethesda, Maryland, United States of America

Sonja Scholz

Affiliations Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America , Reta Lila Weston Institute of Neurological Studies, University College London, London, United Kingdom

Mark R Cookson

Affiliation Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Henry Houlden

Affiliation Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, United Kingdom

Katrina Gwinn-Hardy

Affiliation National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

Hon-Chung Fung

Affiliations Reta Lila Weston Institute of Neurological Studies, University College London, London, United Kingdom , Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America , Department of Neurology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taipei, Taiwan

Xian Lin

Affiliation Transgenics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Dena Hernandez

Affiliation Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Javier Simon-Sanchez

Affiliations Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America , Unitat de Genética Molecular, Departamento de Genómica y Proteómica, Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas, Valencia, Spain

Nick W Wood

Affiliation Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, United Kingdom

Paola Giunti

Affiliation Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, United Kingdom

Ian Rafferty

Affiliation Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

John Hardy

Affiliations Reta Lila Weston Institute of Neurological Studies, University College London, London, United Kingdom , Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Elsdon Storey

Affiliations Department of Medicine, Alfred Hospital, Monash University, Melbourne, Australia , Genetic Health Services Victoria, Melbourne, Australia

R. J. McKinlay Gardner

Affiliations Genetic Health Services Victoria, Melbourne, Australia , Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia

Susan M Forrest

Affiliation Australian Genome Research Facility, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

Elizabeth M. C Fisher

Affiliation Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London, United Kingdom

James T Russell

Affiliation Section on Cell Biology and Signal Transduction, National Institute on Child Health and Development, National Institutes of Health, Bethesda, Maryland, United States of America

Huaibin Cai

Affiliation Transgenics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Andrew B Singleton

To whom correspondence should be addressed. E-mail: singleta@mail.nih.gov

Affiliation Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

EMCF, JTR, and ABS conceived and designed the experiments. JvdL, JC, MAK, LAH, SS, MRC, HCF, XL, DH, JSS, IR, and HC performed the experiments. JvdL, JC, MAK, SS, MRC, KGH, HCF, JSS, JTR, and ABS analyzed the data. HH, NWW, PG, JH, ES, RJMG, SMF, HC, and ABS contributed reagents/materials/analysis tools. RJMG, EMCF, and ABS wrote the paper.