About the Authors

Gema Medina-Gomez

Affiliation Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

Sarah L Gray

Affiliation Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

Laxman Yetukuri

Affiliation Technical Research Centre of Finland (VTT), Espoo, Finland

Kenju Shimomura

Affiliation University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom

Sam Virtue

Affiliation Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

Mark Campbell

Affiliation Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

R. Keira Curtis

Affiliation Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

Mercedes Jimenez-Linan

Affiliation Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

Margaret Blount

Affiliation Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

Giles S. H Yeo

Affiliation Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

Miguel Lopez

Affiliation Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

Tuulikki Seppänen-Laakso

Affiliation Technical Research Centre of Finland (VTT), Espoo, Finland

Frances M Ashcroft

Affiliation University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom

Matej Orešič

Affiliation Technical Research Centre of Finland (VTT), Espoo, Finland

Antonio Vidal-Puig

To whom correspondence should be addressed. E-mail: ajv22@cam.ac.uk

Affiliation Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

GMG, SLG, FMA, and AVP conceived and designed the experiments. GMG, SLG, LY, KS, SV, MB, ML, and MO performed the experiments. GMG, SLG, LY, KS, SV, MC, RKC, MJL, TSL, and MO analysed the data. GMG, LY, KS, SV, MC, RKC, MB, and GSHY contributed reagents/materials/analysis tools. GMG and AVP wrote the paper.