About the Authors

Asger Hobolth

To whom correspondence should be addressed. E-mail: asger@daimi.au.dk

Affiliation Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America

Ole F Christensen

Affiliation Bioinformatics Research Center, University of Aarhus, Aarhus, Denmark

Thomas Mailund

Affiliations Bioinformatics Research Center, University of Aarhus, Aarhus, Denmark , Department of Statistics, University of Oxford, Oxford, United Kingdom

Mikkel H Schierup

Affiliation Bioinformatics Research Center, University of Aarhus, Aarhus, Denmark

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AH, OFC, and MHS conceived and designed the study. AH and MHS analyzed the data. AH developed coal-HMM methodology and software. OFC performed simulation studies. OFC and MHS contributed to coal-HMM methodology. TM wrote simulation software. TM and MHS prepared alignments for data analysis. AH, OFC, and MHS wrote the paper.