About the Authors

Darius Balciunas

Affiliations The Arnold and Mabel Beckman Center for Transposon Research, Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America , Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, United States of America

Kirk J Wangensteen

Contributed equally to this work with: Kirk J Wangensteen, Andrew Wilber

Affiliations The Arnold and Mabel Beckman Center for Transposon Research, Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America , Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America

Andrew Wilber

Contributed equally to this work with: Kirk J Wangensteen, Andrew Wilber

Affiliations The Arnold and Mabel Beckman Center for Transposon Research, Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America , Gene Therapy Program, University of Minnesota, Minneapolis, Minnesota, United States of America

Jason Bell

Affiliation The Arnold and Mabel Beckman Center for Transposon Research, Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America

Aron Geurts

Affiliations The Arnold and Mabel Beckman Center for Transposon Research, Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America , Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, United States of America , Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America

Sridhar Sivasubbu

Affiliations The Arnold and Mabel Beckman Center for Transposon Research, Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America , Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, United States of America

Xin Wang

Affiliations The Arnold and Mabel Beckman Center for Transposon Research, Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America , Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, United States of America

Perry B Hackett

Affiliations The Arnold and Mabel Beckman Center for Transposon Research, Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America , Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, United States of America , Gene Therapy Program, University of Minnesota, Minneapolis, Minnesota, United States of America , Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, United States of America

David A Largaespada

Affiliations The Arnold and Mabel Beckman Center for Transposon Research, Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America , Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, United States of America , Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America

R. Scott McIvor

Affiliations The Arnold and Mabel Beckman Center for Transposon Research, Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America , Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, United States of America , Gene Therapy Program, University of Minnesota, Minneapolis, Minnesota, United States of America , Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America

Stephen C Ekker

To whom correspondence should be addressed. E-mail: ekker001@umn.edu

Affiliations The Arnold and Mabel Beckman Center for Transposon Research, Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America , Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, United States of America , Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America , Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America , Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, United States of America

Competing Interests

We note that the University of Minnesota and PBH, RSM, DAL, and SCE are all founders of a gene therapy company called Discovery Genomics, Incorporated.

Author Contributions

DB, KJW, AW, JB, AG, SS, PBH, DAL, RSM, and SCE conceived and designed the experiments. DB, KJW, AW, JB, AG, and SS performed the experiments. DB, KJW, AW, JB, AG, SS, PBH, DAL, RSM, and SCE analyzed the data. DB, KJW, AW, JB, AG, XW, and DAL contributed reagents/materials/analysis tools. DB, KJW, AW, PBH, RSM, and SCE wrote the paper.