About the Authors

Katherine S Pollard

To whom correspondence should be addressed. E-mail: kspollard@ucdavis.edu

Current address: Genome Center and Department of Statistics, University of California Davis, Davis, California, United States of America

Affiliation Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

Sofie R Salama

Affiliations Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America , Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, California, United States of America

Bryan King

Affiliations Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America , Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, California, United States of America

Andrew D Kern

Affiliation Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

Tim Dreszer

Affiliation Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

Sol Katzman

Affiliations Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America , Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, California, United States of America

Adam Siepel

Current address: Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

Affiliation Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

Jakob S Pedersen

Affiliation Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

Gill Bejerano

Affiliation Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

Robert Baertsch

Affiliation Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

Kate R Rosenbloom

Affiliation Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

Jim Kent

Affiliation Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

David Haussler

Affiliations Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America , Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KSP, SRS, ADK, and DH conceived and designed the experiments. KSP, SRS, BK, ADK, TD, and SK performed the experiments. KSP, SRS, BK, ADK, TD, AS, JSP, and DH analyzed the data. KSP, ADK, AS, JSP, GB, RB, KRR, and JK contributed reagents/materials/analysis tools. KSP, ADK, and DH wrote the paper.