About the Authors

Kevin Fitzgerald

Affiliation Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

Svetlana Tertyshnikova

Affiliation Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

Lisa Moore

Affiliation Exelixis Incorporated, South San Francisco, California, United States of America

Lynn Bjerke

Affiliation Exelixis Incorporated, South San Francisco, California, United States of America

Ben Burley

Affiliation Exelixis Incorporated, South San Francisco, California, United States of America

Jian Cao

Affiliation Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

Pamela Carroll

Affiliation Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

Robert Choy

Affiliation Exelixis Incorporated, South San Francisco, California, United States of America

Steve Doberstein

Affiliation Exelixis Incorporated, South San Francisco, California, United States of America

Yves Dubaquie

Affiliation Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

Yvonne Franke

Affiliation Exelixis Incorporated, South San Francisco, California, United States of America

Jenny Kopczynski

Affiliation Exelixis Incorporated, South San Francisco, California, United States of America

Hendrik Korswagen

Affiliation Hubrecht Laboratory, Centre for Biomedical Genetics, Utrecht, Netherlands

Stanley R Krystek Jr.

Affiliation Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

Nicholas J Lodge

Affiliation Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

Ronald Plasterk

Affiliation Hubrecht Laboratory, Centre for Biomedical Genetics, Utrecht, Netherlands

John Starrett

Affiliation Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

Terry Stouch

Affiliation Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

George Thalody

Affiliation Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

Honey Wayne

Affiliation Exelixis Incorporated, South San Francisco, California, United States of America

Alexander van der Linden

Affiliation Hubrecht Laboratory, Centre for Biomedical Genetics, Utrecht, Netherlands

Yongmei Zhang

Affiliation Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

Stephen G Walker

Affiliation Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

Mark Cockett

Affiliation Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

Judi Wardwell-Swanson

Affiliation Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

Petra Ross-Macdonald

To whom correspondence should be addressed. E-mail: Petra.RossMacdonald@bms.com

Affiliation Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

Rachel M Kindt

Affiliation Exelixis Incorporated, South San Francisco, California, United States of America

Competing Interests

This research was funded by Bristol-Myers Squibb and Exelixis Incorporated.

Author Contributions

KF, ST, LM, JC, PC, RC, SD, JK, NJL, SGW, MC, JWS, PRM, and RMK conceived and designed the experiments. KF, ST, LM, LB, BB, JC, RC, YF, HW, YZ, SGW, JWS, and RMK performed the experiments. KF, ST, LM, PC, RC, JK, YZ, SGW, JWS, PRM, and RMK analyzed the data. ST, YD, HK, SRK, Jr., NJL, RP, JS, TS, GT, and AvdL contributed reagents/materials/analysis tools. KF, PRM, and RMK wrote the paper.