About the Authors

Xu-Gang Xia

Contributed equally to this work with: Xu-Gang Xia, Hongxia Zhou

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Hongxia Zhou

Contributed equally to this work with: Xu-Gang Xia, Hongxia Zhou

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Enrique Samper

Affiliation Buck Institute for Age Research, Novato, California, United States of America

Simon Melov

Affiliation Buck Institute for Age Research, Novato, California, United States of America

Zuoshang Xu

To whom correspondence should be addressed. E-mail: zuoshang.xu@umassmed.edu

Affiliations Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America , Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America , Neuroscience Program, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Competing Interests

XGX, HZ, and ZX are authors of a pending patent on the Pol II–shRNA construct used in this study.

Author Contributions

XGX, HZ, and ZX conceived and designed the experiments. XGX, HZ, ES, and SM performed the experiments. XGX, HZ, ES, SM, and ZX analyzed the data. XGX, HZ, ES, and SM contributed reagents/materials/analysis tools. ZX wrote the paper.