About the Authors

Marie Lagouge

Current address: Inserm U1138, Centre de Recherche des Cordeliers, Paris, France

Affiliation Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, Germany

Arnaud Mourier

Affiliation Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, Germany

Hyun Ju Lee

Affiliation Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, Germany

Henrik Spåhr

Affiliation Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, Germany

Timothy Wai

Affiliation CECAD Research Center, University of Cologne, Cologne, Germany

Christian Kukat

Affiliation FACS and Imaging facility, Max Planck Institute for Biology of Ageing, Cologne, Germany

Eduardo Silva Ramos

Affiliation Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, Germany

Elisa Motori

Affiliation Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, Germany

Jakob D. Busch

Affiliation Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, Germany

Stefan Siira

Affiliation Harry Perkins Institute of Medical Research, Centre for Medical Research and School of Chemistry and Biochemistry, The University of Western Australia, Perth, Australia

German Mouse Clinic Consortium

The members of the German Mouse Clinic Consortium are listed in the S1 Text.

Affiliation German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany

Elisabeth Kremmer

Affiliation Helmholtz Zentrum München, Institute of Molecular Immunology, Munich, Germany

Aleksandra Filipovska

aleksandra.filipovska@uwa.edu.au (AF); larsson@age.mpg.de (NGL)

Affiliation Harry Perkins Institute of Medical Research, Centre for Medical Research and School of Chemistry and Biochemistry, The University of Western Australia, Perth, Australia

Nils-Göran Larsson

aleksandra.filipovska@uwa.edu.au (AF); larsson@age.mpg.de (NGL)

Affiliations Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, Germany, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ML AF NGL. Performed the experiments: ML AM HJL HS TW CK ESR EM JDB SS EK AF. Analyzed the data: ML AM HJL HS TW CK ESR EM JDB SS AF. Wrote the paper: ML AF NGL.