About the Authors

Bruno A. Benitez

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

Celeste M. Karch

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

Yefei Cai

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

Sheng Chih Jin

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

Breanna Cooper

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

David Carrell

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

Sarah Bertelsen

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

Lori Chibnik

Affiliations Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard University and M.I.T., Cambridge, Massachusetts, United States of America

Julie A. Schneider

Affiliation Rush Alzheimer's Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America

David A. Bennett

Affiliation Rush Alzheimer's Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America

Alzheimer's Disease Neuroimaging Initiative (ADNI)

Data used in preparation of this article were obtained from the Alzheimer 's Disease Neuroimaging Initiative (ADNI) database (adni.loni.ucla.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.ucla.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf

Genetic and Environmental Risk for Alzheimer's Disease Consortium (GERAD1)

‡ Data used in the preparation of this article were obtained from the Genetic and Environmental Risk for Alzheimer's Disease (GERAD1) Consortium. As such, the investigators within the GERAD1 consortia contributed to the design and implementation of GERAD1 and/or provided data but did not participate in analysis or writing of this report. A full list of GERAD investigators can be found in Supporting Information.

Anne M. Fagan

Affiliations Department of Neurology, School of Medicine, Washington University, St. Louis, Missouri, United States of America, Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University St. Louis, Missouri, United States of America

David Holtzman

Affiliations Department of Neurology, School of Medicine, Washington University, St. Louis, Missouri, United States of America, Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University St. Louis, Missouri, United States of America

John C. Morris

Affiliations Department of Neurology, School of Medicine, Washington University, St. Louis, Missouri, United States of America, Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University St. Louis, Missouri, United States of America

Alison M. Goate

Affiliations Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America, Department of Neurology, School of Medicine, Washington University, St. Louis, Missouri, United States of America, Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University St. Louis, Missouri, United States of America, Department of Genetics, School of Medicine, Washington University, St. Louis, Missouri, United States of America

Carlos Cruchaga

cruchagac@psychiatry.wustl.edu

Affiliations Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America, Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University St. Louis, Missouri, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BAB AMG CC. Performed the experiments: BAB CC CMK SCJ BC DC. Analyzed the data: BAB CC SCJ YC SB LC. Contributed reagents/materials/analysis tools: JAS DAB ADNI GERAD1 AMF DH JM. Wrote the paper: BAB CC