About the Authors

Xin He

Affiliation Lane Center of Computational Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

Stephan J. Sanders

Affiliation Departments of Psychiatry and Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America

Li Liu

Affiliation Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

Silvia De Rubeis

Affiliations Seaver Autism Center for Research and Treatment, Icahn Mount Sinai School of Medicine, New York, New York, United States of America, Department of Psychiatry, Icahn Mount Sinai School of Medicine, New York, New York, United States of America

Elaine T. Lim

Affiliations Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

James S. Sutcliffe

Affiliation Vanderbilt Brain Institute, Departments of Molecular Physiology & Biophysics and Psychiatry, Vanderbilt University, Nashville, Tennessee, United States of America

Gerard D. Schellenberg

Affiliation Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Richard A. Gibbs

Affiliation Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

Mark J. Daly

Affiliations Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Joseph D. Buxbaum

Affiliations Seaver Autism Center for Research and Treatment, Icahn Mount Sinai School of Medicine, New York, New York, United States of America, Department of Psychiatry, Icahn Mount Sinai School of Medicine, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Icahn Mount Sinai School of Medicine, New York, New York, United States of America, Friedman Brain Institute, Icahn Mount Sinai School of Medicine, New York, New York, United States of America

Matthew W. State

Affiliation Departments of Psychiatry and Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America

Bernie Devlin

Affiliation Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Kathryn Roeder

roeder@stat.cmu.edu

Affiliations Lane Center of Computational Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America, Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XH BD KR. Performed the experiments: XH SJS LL SDR. Analyzed the data: XH SJS LL KR. Contributed reagents/materials/analysis tools: XH SJS LL SDR ETL JSS GDS RAG MJD JDB MWS BD KR. Wrote the paper: XH SJS BD KR.