About the Authors

Fanggeng Zou

Contributed equally to this work with: Fanggeng Zou, High Seng Chai, Curtis S. Younkin, Mariet Allen

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

High Seng Chai

Contributed equally to this work with: Fanggeng Zou, High Seng Chai, Curtis S. Younkin, Mariet Allen

Affiliation Department of Biostatistics, Mayo Clinic, Rochester, Minnesota, United States of America

Curtis S. Younkin

Contributed equally to this work with: Fanggeng Zou, High Seng Chai, Curtis S. Younkin, Mariet Allen

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

Mariet Allen

Contributed equally to this work with: Fanggeng Zou, High Seng Chai, Curtis S. Younkin, Mariet Allen

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

Julia Crook

Affiliation Department of Biostatistics, Mayo Clinic, Jacksonville, Florida, United States of America

V. Shane Pankratz

Affiliation Department of Biostatistics, Mayo Clinic, Rochester, Minnesota, United States of America

Minerva M. Carrasquillo

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

Christopher N. Rowley

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

Asha A. Nair

Affiliation Department of Biostatistics, Mayo Clinic, Rochester, Minnesota, United States of America

Sumit Middha

Affiliation Department of Biostatistics, Mayo Clinic, Rochester, Minnesota, United States of America

Sooraj Maharjan

Affiliation Department of Biostatistics, Mayo Clinic, Rochester, Minnesota, United States of America

Thuy Nguyen

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

Li Ma

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

Kimberly G. Malphrus

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

Ryan Palusak

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

Sarah Lincoln

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

Gina Bisceglio

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

Constantin Georgescu

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

Naomi Kouri

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

Christopher P. Kolbert

Affiliation Microarray Core, Mayo Clinic, Rochester, Minnesota, United States of America

Jin Jen

Affiliation Microarray Core, Mayo Clinic, Rochester, Minnesota, United States of America

Jonathan L. Haines

Affiliation Department of Molecular Physiology and Biophysics and Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

Richard Mayeux

Affiliation Gertrude H. Sergievsky Center, Department of Neurology, and Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, United States of America

Margaret A. Pericak-Vance

Affiliation The John P. Hussman Institute for Human Genomics and Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America

Lindsay A. Farrer

Affiliation Departments of Biostatistics, Medicine (Genetics Program), Ophthalmology, Neurology, and Epidemiology, Boston University, Boston, Massachusetts, United States of America

Gerard D. Schellenberg

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

Alzheimer's Disease Genetics Consortium

Membership of the Alzheimer's Disease Genetics Consortium (ADGC) is provided in the Acknowledgments.

Ronald C. Petersen

Affiliation Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America

Neill R. Graff-Radford

Affiliation Department of Neurology, Mayo Clinic, Jacksonville, Florida, United States of America

Dennis W. Dickson

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

Steven G. Younkin

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

Nilüfer Ertekin-Taner

taner.nilufer@mayo.edu

Affiliations Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America, Department of Neurology, Mayo Clinic, Jacksonville, Florida, United States of America

Competing Interests

NR Graff-Radford has served as a consultant to Codman and received grant support from Elan Pharmaceutical Research, Pfizer Pharmaceuticals, Medivation, and Forrest. RC Petersen has been a consultant to GE Healthcare and Elan Pharmaceuticals, has served on a data safety monitoring committee for Pfizer and Janssen Alzheimer Immunotherapy, and has provided a CME lecture for Novartis. ADGC Authors: T.D.B. received licensing fees from and is on the speaker's bureau of Athena Diagnostics. M.R.F. receives research funding from BristolMyersSquibb Company, Danone Research, Elan Pharmaceuticals, Eli Lilly, Novartis Pharmaceuticals, OctaPharma AG, Pfizer, and Sonexa Therapeutics; receives honoraria as scientific consultant from Accera, Astellas Pharma US Inc., Baxter, Bayer Pharmaceuticals Corporation, BristolMyersSquibb, Eisai Medical Research, GE Healthcare, Medavante, Medivation, Merck, Novartis Pharmaceuticals, Pfizer, Prana Biotechnology, QR Pharma, The sanofi-aventis Group, and Toyama Chemical; and is speaker for Eisai Medical Research, Forest Laboratories, Pfizer, and Novartis Pharmaceuticals. A.M.G. has research funding from AstraZeneca, Pfizer and Genentech, and has received remuneration for giving talks at Pfizer and Genentech. R.C.P. is on the Safety Monitory Committee of Pfizer (Wyeth) and a consultant to the Safety Monitoring Committee at Janssen Alzheimer's Immunotherapy Program (Elan), to Elan Pharmaceuticals, and to GE Healthcare. R.E.T. is a consultant to Eisai, Japan, in the area of Alzheimer's genetics and a shareholder in, and consultant to, Pathway Genomics, San Diego, CA.

Author Contributions

Conceived and designed the experiments: SG Younkin, N Ertekin-Taner. Performed the experiments: F Zou, MM Carrasquillo, CN Rowley, T Nguyen, L Ma, KG Malphrus, R Palusak, S Lincoln, G Bisceglio, N Kouri, CP Kolbert, J Jen. Analyzed the data: F Zou, HS Chai, CS Younkin, J Crook, VS Pankratz, M Allen, MM Carrasquillo, AA Nair, S Middha, S Maharjan, C Gorgescu, SG Younkin, N Ertekin-Taner. Contributed reagents/materials/analysis tools: Alzheimer's Disease Genetics Consortium, JL Haines, R Mayeux, MA Pericak-Vance, LA Farrer, GD Schellenberg, RC Petersen, NR Graff-Radford, DW Dickson, SG Younkin. Wrote the paper: F Zou, HS Chai, CS Younkin, J Crook, VS Pankratz, M Allen, SG Younkin, N Ertekin-Taner.