The Caenorhabditis elegans Synthetic Multivulva Genes Prevent Ras Pathway Activation by Tightly Repressing Global Ectopic Expression of lin-3 EGF

Adam M. Saffer; Dong Hyun Kim; Alexander van Oudenaarden; H. Robert Horvitz

doi:10.1371/journal.pgen.1002418

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Peer-reviewed

Research Article

The Caenorhabditis elegans Synthetic Multivulva Genes Prevent Ras Pathway Activation by Tightly Repressing Global Ectopic Expression of lin-3 EGF

Adam M. Saffer,

Affiliations Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Dong Hyun Kim,

Affiliation Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Alexander van Oudenaarden,

Affiliations Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
H. Robert Horvitz

* E-mail: horvitz@mit.edu

Affiliations Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯

The Caenorhabditis elegans Synthetic Multivulva Genes Prevent Ras Pathway Activation by Tightly Repressing Global Ectopic Expression of lin-3 EGF

Adam M. Saffer,
Dong Hyun Kim,
Alexander van Oudenaarden,
H. Robert Horvitz

Published: December 29, 2011
https://doi.org/10.1371/journal.pgen.1002418

About the Authors

Adam M. Saffer

Affiliations Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Dong Hyun Kim

Affiliation Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Alexander van Oudenaarden

Affiliations Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

H. Robert Horvitz

* E-mail: horvitz@mit.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AMS DHK AvO HRH. Performed the experiments: AMS DHK. Analyzed the data: AMS DHK HRH. Wrote the paper: AMS HRH.

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Nonsense mutation
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Gene expression
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Tumor suppressor genes
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Pharynx
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Caenorhabditis elegans
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Messenger RNA
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