About the Authors
- Ian P. M. Tomlinson
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Contributed equally to this work with: Ian P. M. Tomlinson, Luis G. Carvajal-Carmona
* E-mail: iant@well.ox.ac.uk (IPMT); richard.houlston@icr.ac.uk (RSH); malcolm.dunlop@hgu.mrc.ac.uk (MGD)
Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- Luis G. Carvajal-Carmona
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Contributed equally to this work with: Ian P. M. Tomlinson, Luis G. Carvajal-Carmona
Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- Sara E. Dobbins
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Affiliation Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom
- Albert Tenesa
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Affiliation Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council Human Genetics Unit, Edinburgh, United Kingdom
- Angela M. Jones
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Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- Kimberley Howarth
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Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- Claire Palles
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Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- Peter Broderick
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Affiliation Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom
- Emma E. M. Jaeger
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Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- Susan Farrington
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Affiliation Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council Human Genetics Unit, Edinburgh, United Kingdom
- Annabelle Lewis
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Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- James G. D. Prendergast
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Affiliation Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council Human Genetics Unit, Edinburgh, United Kingdom
- Alan M. Pittman
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Affiliation Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom
- Evropi Theodoratou
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Affiliation The University of Edinburgh Medical School, Edinburgh, United Kingdom
- Bianca Olver
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Affiliation Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom
- Marion Walker
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Affiliation Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council Human Genetics Unit, Edinburgh, United Kingdom
- Steven Penegar
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Affiliation Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom
- Ella Barclay
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Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- Nicola Whiffin
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Affiliation Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom
- Lynn Martin
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Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- Stephane Ballereau
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Affiliation Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council Human Genetics Unit, Edinburgh, United Kingdom
- Amy Lloyd
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Affiliation Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom
- Maggie Gorman
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Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- Steven Lubbe
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Affiliation Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom
- The COGENT Consortium
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¶Memberships of the consortia are provided in
Text S1 . - The CORGI Collaborators
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¶Memberships of the consortia are provided in
Text S1 . - The EPICOLON Consortium
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¶Memberships of the consortia are provided in
Text S1 . - Bryan Howie
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Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom
- Jonathan Marchini
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Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom
- Clara Ruiz-Ponte
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Affiliation Galician Public Foundation of Genomic Medicine (FPGMX), Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER), Genomics Medicine Group, Hospital Clinico, Santiago de Compostela, University of Santiago de Compostela, Galicia, Spain
- Ceres Fernandez-Rozadilla
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Affiliation Galician Public Foundation of Genomic Medicine (FPGMX), Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER), Genomics Medicine Group, Hospital Clinico, Santiago de Compostela, University of Santiago de Compostela, Galicia, Spain
- Antoni Castells
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Affiliation Department of Gastroenterology, Hospital Clinic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain
- Angel Carracedo
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Affiliation Galician Public Foundation of Genomic Medicine (FPGMX), Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER), Genomics Medicine Group, Hospital Clinico, Santiago de Compostela, University of Santiago de Compostela, Galicia, Spain
- Sergi Castellvi-Bel
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Affiliation Department of Gastroenterology, Hospital Clinic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain
- David Duggan
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Affiliation Translational Genomics Research Institute, Phoenix, Arizona, United States of America
- David Conti
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Affiliation Department of Preventive Medicine, University of Southern California, Los Angeles, California, United States of America
- Jean-Baptiste Cazier
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Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- Harry Campbell
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Affiliation Public Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
- Oliver Sieber
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Affiliation Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Australia
- Lara Lipton
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Affiliation Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Australia
- Peter Gibbs
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Affiliation Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Australia
- Nicholas G. Martin
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Affiliation Genetic and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Brisbane, Australia
- Grant W. Montgomery
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Affiliation Genetic and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Brisbane, Australia
- Joanne Young
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Affiliation Familial Cancer Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
- Paul N. Baird
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Affiliation Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
- Steven Gallinger
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Affiliation Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
- Polly Newcomb
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Affiliation Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
- John Hopper
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Affiliation Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia
- Mark A. Jenkins
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Affiliation Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia
- Lauri A. Aaltonen
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Affiliation Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
- David J. Kerr
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Affiliation Department of Clinical Pharmacology, University of Oxford, Oxford, United Kingdom
- Jeremy Cheadle
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Affiliation Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom
- Paul Pharoah
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Affiliation Cancer Research UK Laboratories, Strangeways Research Laboratory, Department of Oncology, University of Cambridge, Cambridge, United Kingdom
- Graham Casey
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Affiliation Department of Preventive Medicine, University of Southern California, Los Angeles, California, United States of America
- Richard S. Houlston
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* E-mail: iant@well.ox.ac.uk (IPMT); richard.houlston@icr.ac.uk (RSH); malcolm.dunlop@hgu.mrc.ac.uk (MGD)
Affiliation Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom
- Malcolm G. Dunlop
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* E-mail: iant@well.ox.ac.uk (IPMT); richard.houlston@icr.ac.uk (RSH); malcolm.dunlop@hgu.mrc.ac.uk (MGD)
Affiliation Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council Human Genetics Unit, Edinburgh, United Kingdom
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: IPM Tomlinson, RS Houlston, MG Dunlop. Performed the experiments: LG Carvajal-Carmona, AM Jones, K Howarth, P Broderick, EEM Jaeger, S Farrington, A Lewis, JGD Pendergast, AM Pittman, B Olver, M Walker, N Whiffin, C Ruiz-Ponte, C Fernandez-Rozadilla. Analyzed the data: IPM Tomlinson, LG Carvajal-Carmona, SE Dobbins, A Tenesa, AM Jones, C Palles, E Theodoratou, S Ballereau, A Lloyd, J-B Cazier. Contributed reagents/materials/analysis tools: S Penegar, E Barclay, L Martin, M Gorman, S Lubbe, B Howie, J Marchini, A Castells, A Carracedo, S Castellvi-Bel, D Duggan, D Conti, H Campbell, O Sieber, L Lipton, P Gibbs, NG Martin, GW Montgomery, J Young, PN Baird, P Newcomb, J Hopper, MA Jenkins, LA Aaltonen, DJ Kerr, J Cheadle, P Pharoah, G Casey, S Gallinger. Wrote the paper: IPM Tomlinson, RS Houlston, MG Dunlop.