About the Authors
- Alexandra Zhernakova
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Affiliations Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Complex Genetics Section, Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
- Eli A. Stahl
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Affiliations Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America
- Gosia Trynka
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Affiliation Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands
- Soumya Raychaudhuri
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Affiliations Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
- Eleanora A. Festen
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Affiliation Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands
- Lude Franke
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Affiliations Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
- Harm-Jan Westra
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Affiliation Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands
- Rudolf S. N. Fehrmann
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Affiliation Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands
- Fina A. S. Kurreeman
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Affiliations Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America
- Brian Thomson
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Affiliation Broad Institute, Cambridge, Massachusetts, United States of America
- Namrata Gupta
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Affiliation Broad Institute, Cambridge, Massachusetts, United States of America
- Jihane Romanos
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Affiliation Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands
- Ross McManus
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Affiliation Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College, St James's Hospital, Dublin, Ireland
- Anthony W. Ryan
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Affiliation Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College, St James's Hospital, Dublin, Ireland
- Graham Turner
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Affiliation Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College, St James's Hospital, Dublin, Ireland
- Elisabeth Brouwer
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Affiliation Department of Rheumatology and Clinical Immunology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
- Marcel D. Posthumus
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Affiliation Department of Rheumatology and Clinical Immunology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
- Elaine F. Remmers
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Affiliation Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
- Francesca Tucci
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Affiliation European Laboratory for Food Induced Disease, University of Naples Federico II, Naples, Italy
- Rene Toes
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Affiliation Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
- Elvira Grandone
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Affiliation Unita' di Aterosclerosi e Trombosi, I.R.C.C.S Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Foggia, Italy
- Maria Cristina Mazzilli
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Affiliation Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
- Anna Rybak
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Affiliation Department of Gastroenterology, Hepatology, and Immunology, Children's Memorial Health Institute, Warsaw, Poland
- Bozena Cukrowska
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Affiliation Department of Pathology, Children's Memorial Health Institute, Warsaw, Poland
- Marieke J. H. Coenen
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Affiliation Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
- Timothy R. D. J. Radstake
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Affiliation Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
- Piet L. C. M. van Riel
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Affiliation Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
- Yonghong Li
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Affiliation Celera, Alameda, California, United States of America
- Paul I. W. de Bakker
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Affiliations Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
- Peter K. Gregersen
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Affiliation The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America
- Jane Worthington
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Affiliation Arthritis Research Campaign–Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
- Katherine A. Siminovitch
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Affiliation Department of Medicine, University of Toronto, Mount Sinai Hospital and University Health Network, Toronto, Canada
- Lars Klareskog
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Affiliation Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden
- Tom W. J. Huizinga
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Affiliation Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
- Cisca Wijmenga
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Contributed equally to this work with: Cisca Wijmenga, Robert M. Plenge
Affiliation Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands
- Robert M. Plenge
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Contributed equally to this work with: Cisca Wijmenga, Robert M. Plenge
* E-mail: rplenge@partners.org
Affiliations Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Competing Interests
YL has employment and stock interest in Celera.
Author Contributions
Conceived and designed the experiments: RM Plenge, C Wijmenga, A Zhernakova, EA Stahl, S Raychaudhuri. Performed the experiments: A Zhernakova, G Trynka, FAS Kurreeman, B Thomson, N Gupta, J Romanos, EF Remmers, Y Li. Analyzed the data: A Zhernakova, EA Stahl, RM Plenge, S Raychaudhuri, L Franke, RSN Fehrmann, EA Festen, FAS Kurreeman, PIW de Bakker, HJ Westra. Contributed reagents/materials/analysis tools: RM Plenge, C Wijmenga, A Zhernakova, R McManus, AW Ryan, G Turner, PK Gregersen, J Worthington, KA Siminovitch, L Klareskog, TWJ Huizinga, EF Remmers, F Tucci, R Toes, E Grandone, MC Mazzilli, A Rybak, B Cukrowska, E Brouwer, MD Posthumus, MJH Coenen, TRDJ Radstake, PLCM van Riel. Wrote the paper: RM Plenge, C Wijmenga, A Zhernakova, EA Stahl, S Raychaudhuri, FAS Kurreeman, G Trynka, R Toes, Y Li, TWJ Huizinga.