About the Authors

Carlos Cruchaga

Contributed equally to this work with: Carlos Cruchaga, John S. K. Kauwe

cruchagc@psychiatry.wustl.edu

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America, The Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN), Washington University School of Medicine, St. Louis, Missouri, United States of America

John S. K. Kauwe

Contributed equally to this work with: Carlos Cruchaga, John S. K. Kauwe

Affiliation Department of Biology, Brigham Young University, Provo, Utah, United States of America

Kevin Mayo

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America, The Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN), Washington University School of Medicine, St. Louis, Missouri, United States of America

Noah Spiegel

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America, The Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN), Washington University School of Medicine, St. Louis, Missouri, United States of America

Sarah Bertelsen

Affiliation Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America

Petra Nowotny

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America, The Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN), Washington University School of Medicine, St. Louis, Missouri, United States of America

Aarti R. Shah

Affiliations The Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN), Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Richard Abraham

Affiliation Department of Neurology, University of Washington School of Medicine, Seattle, Washington, United States of America

Paul Hollingworth

Affiliation Department of Psychological Medicine, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom

Denise Harold

Affiliation Department of Psychological Medicine, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom

Michael M. Owen

Affiliation Department of Psychological Medicine, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom

Julie Williams

Affiliation Department of Psychological Medicine, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom

Simon Lovestone

Affiliation Kings College, London, United Kingdom

Elaine R. Peskind

Affiliations Departments of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, United States of America, Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Seattle, Washington, United States of America

Ge Li

Affiliations Departments of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, United States of America, Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Seattle, Washington, United States of America

James B. Leverenz

Affiliations Departments of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, United States of America, Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Seattle, Washington, United States of America, Department of Neurology, University of Washington School of Medicine, Seattle, Washington, United States of America

Douglas Galasko

Affiliation Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America

The Alzheimer's Disease Neuroimaging Initiative

A complete listing of the investigators for the Alzheimer's Disease Neuroimaging Initiative is provided in the Acknowledgments.

John C. Morris

Affiliations Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Kings College, London, United Kingdom

Anne M. Fagan

Affiliations The Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN), Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

David M. Holtzman

Affiliations The Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN), Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

Alison M. Goate

Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America, The Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN), Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

Competing Interests

The work presented in this report is also the subject of a pending patent filed by Washington University in St. Louis, Missouri, United States of America, in which Drs. C. Cruchaga, A. M. Goate, D. M. Holtzman and A. Fagan are named as inventors. The patent is currently under option to AstraZeneca Pharmaceuticals, LP. Drs. Goate and Holtzman have acted as consultants for AstraZeneca Pharmaceuticals, LP, in 2008/2009.

Author Contributions

Conceived and designed the experiments: CC JSKK AMG. Performed the experiments: CC KM NS ARS. Analyzed the data: CC JSKK SB PN. Contributed reagents/materials/analysis tools: RA PH DH MMO JW SL ERP GL JBL DG The Alzheimer's Disease Neuroimaging Initiative JCM AMF DMH. Wrote the paper: CC AMG.