About the Authors

Zhenglin Yang

Contributed equally to this work with: Zhenglin Yang, Zongzhong Tong, Yuhong Chen

kangzhang@ucsd.edu (KZ); nkatsan1@jhmi.edu (NK); zliny@yahoo.com (ZY)

Affiliations Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, San Diego, California, United States of America, Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Zongzhong Tong

Contributed equally to this work with: Zhenglin Yang, Zongzhong Tong, Yuhong Chen

Affiliation Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Yuhong Chen

Contributed equally to this work with: Zhenglin Yang, Zongzhong Tong, Yuhong Chen

Affiliations Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, San Diego, California, United States of America, Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Jiexi Zeng

Affiliations Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, San Diego, California, United States of America, Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Fang Lu

Affiliation Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

Xufang Sun

Affiliations Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, San Diego, California, United States of America, Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Chao Zhao

Affiliations Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, San Diego, California, United States of America, Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Kevin Wang

Affiliation Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, San Diego, California, United States of America

Lisa Davey

Affiliation Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

Haoyu Chen

Affiliation Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Nyall London

Affiliation Program in Human Molecular Biology and Genetics, Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Daisuke Muramatsu

Affiliation Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, United States of America

Francesca Salasar

Affiliation Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, San Diego, California, United States of America

Ruben Carmona

Affiliation Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, San Diego, California, United States of America

Daniel Kasuga

Affiliation Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, San Diego, California, United States of America

Xiaolei Wang

Affiliation Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, San Diego, California, United States of America

Matthew Bedell

Affiliation Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, San Diego, California, United States of America

Manjuxia Dixie

Affiliation Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Peiquan Zhao

Affiliation Departmet of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University, Shanghai, China

Ruifu Yang

Affiliation Laboratory of Analytical Microbiology, Institute of Microbiology and Epidemiology, Beijing, China

Daniel Gibbs

Affiliation Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Xiaoqi Liu

Affiliation Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

Yan Li

Affiliation Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

Cai Li

Affiliation Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

Yuanfeng Li

Affiliation Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

Betsy Campochiaro

Affiliation Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, United States of America

Ryan Constantine

Affiliation Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Donald J. Zack

Affiliation Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, United States of America

Peter Campochiaro

Affiliation Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, United States of America

Yinbin Fu

Affiliation Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Dean Y. Li

Affiliation Program in Human Molecular Biology and Genetics, Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

Nicholas Katsanis

kangzhang@ucsd.edu (KZ); nkatsan1@jhmi.edu (NK); zliny@yahoo.com (ZY)

Affiliations Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, Maryland, United States of America

Kang Zhang

kangzhang@ucsd.edu (KZ); nkatsan1@jhmi.edu (NK); zliny@yahoo.com (ZY)

Affiliations Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, San Diego, California, United States of America, Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, United States of America, Veteran's Administration, San Diego, California, United States of America, Department of Ophthalmology and Ophthalmic Laboratories, West China Hospital, Sichuan, China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZY NK KZ. Performed the experiments: ZY ZT JZ FL XS CZ KW LD HC NL DM FS RC DK XW MD PZ RY DG XL YL CL YL BC RC. Analyzed the data: ZY YC HC DG DYL KZ. Contributed reagents/materials/analysis tools: ZY RY BC DJZ PC YF NK KZ. Wrote the paper: ZY MB DYL NK KZ.