Human MLH1 Protein Participates in Genomic Damage Checkpoint Signaling in Response to DNA Interstrand Crosslinks, while MSH2 Functions in DNA Repair

Qi Wu; Karen M. Vasquez

doi:10.1371/journal.pgen.1000189

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Open Access

Peer-reviewed

Research Article

Human MLH1 Protein Participates in Genomic Damage Checkpoint Signaling in Response to DNA Interstrand Crosslinks, while MSH2 Functions in DNA Repair

Qi Wu,

Affiliation Department of Carcinogenesis, University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas, United States of America
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Karen M. Vasquez

* E-mail: kvasquez@mdanderson.org

Affiliation Department of Carcinogenesis, University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas, United States of America
⨯

Human MLH1 Protein Participates in Genomic Damage Checkpoint Signaling in Response to DNA Interstrand Crosslinks, while MSH2 Functions in DNA Repair

Qi Wu,
Karen M. Vasquez

Published: September 12, 2008
https://doi.org/10.1371/journal.pgen.1000189

About the Authors

Qi Wu

Affiliation Department of Carcinogenesis, University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas, United States of America

Karen M. Vasquez

* E-mail: kvasquez@mdanderson.org

Affiliation Department of Carcinogenesis, University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: QW KMV. Performed the experiments: QW. Analyzed the data: QW KMV. Contributed reagents/materials/analysis tools: QW KMV. Wrote the paper: QW KMV.

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Apoptosis
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Cancer treatment
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Ultraviolet A
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DNA repair
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Small interfering RNA
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Phosphorylation
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Oligonucleotides
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