About the Authors
- Dirk A Kleinjan
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Contributed equally to this work with: Dirk A Kleinjan, Ruth M Bancewicz
Affiliation Medical Research Council (MRC) Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
- Ruth M Bancewicz
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Contributed equally to this work with: Dirk A Kleinjan, Ruth M Bancewicz
Current address: The Faraday Institute for Science and Religion, St Edmund's College, Cambridge, UK
Affiliation Medical Research Council (MRC) Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
- Philippe Gautier
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Affiliation Medical Research Council (MRC) Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
- Ralf Dahm
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Current address: Center for Brain Research, Medical University of Vienna, Vienna, Austria
Affiliation Department of Genetics, Max-Planck Institute for Developmental Biology, Tübingen, Germany
- Helia B Schonthaler
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Current address: Research Institute of Molecular Pathology, Vienna, Austria
Affiliation Department of Genetics, Max-Planck Institute for Developmental Biology, Tübingen, Germany
- Giuseppe Damante
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Affiliation Department of Science and Biomedical Technology, University of Udine, Udine, Italy
- Anne Seawright
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Affiliation Medical Research Council (MRC) Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
- Ann M Hever
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Affiliation Medical Research Council (MRC) Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
- Patricia L Yeyati
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Affiliation Medical Research Council (MRC) Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
- Veronica van Heyningen
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*To whom correspondence should be addressed. E-mail: v.vanheyningen@hgu.mrc.ac.uk
Affiliation Medical Research Council (MRC) Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
- Pedro Coutinho
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Affiliation Medical Research Council (MRC) Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
DAK, RMB, VvH, and PC conceived and designed the experiments and analyzed the data with significant input by PLY. RMB carried out the mating and phenotype selection and confirmations for the mapping. DAK and PC developed the transgenic strategies and constructs and made and analyzed mouse and fish transgenics with help from AS. PC carried out mRNA rescue and morpholino experiments. PG and PC provided bioinformatics contributions. RD supplied the sunrise mutant and worked with HBS on the fish mapping. RD and PLY analyzed the fish eye phenotype. AMH analyzed the pancreas. GD conceived and carried out the mutant protein functional analyses. VvH wrote the paper.