About the Authors

Carrie M Garrett-Engele

Affiliations Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America , Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

Michael A Tasch

Affiliations Department of Immunology, University of Washington, Seattle, Washington, United States of America , Department of Biochemistry, University of Washington, Seattle, Washington, United States of America , Department of Medicine, University of Washington, Seattle, Washington, United States of America

Harry C Hwang

Affiliations Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America , Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Matthew L Fero

Affiliation Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Roger M Perlmutter

¤ Current address: Amgen Inc., Thousand Oaks, California, United States of America

Affiliations Department of Immunology, University of Washington, Seattle, Washington, United States of America , Department of Biochemistry, University of Washington, Seattle, Washington, United States of America , Department of Medicine, University of Washington, Seattle, Washington, United States of America , Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

Bruce E Clurman

Affiliations Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America , Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

James M Roberts

To whom correspondence should be addressed. E-mail: jroberts@fhcrc.org

Affiliations Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America , Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CMGE, MAT, RMP, and JMR conceived and designed the experiments. CMGE and MAT performed the experiments. CMGE, MAT, RMP, BEC, and JMR analyzed the data. HCH, MLF, and BEC contributed reagents/materials/analysis tools. CMGE, MAT, and JMR wrote the paper.