About the Authors

Jen-Tsan Chi

Affiliations The Institute for Genome Sciences and Policy, Duke University School of Medicine, Durham, North Carolina, United States of America , Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America

Edwin H Rodriguez

Affiliation Department of Biochemistry, Stanford University School of Medicine, Palo Alto, California, United States of America

Zhen Wang

Affiliation Department of Surgery, Stanford University School of Medicine, Palo Alto, California, United States of America

Dimitry S. A Nuyten

Affiliation Diagnostic Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Sayan Mukherjee

Affiliations The Institute for Genome Sciences and Policy, Duke University School of Medicine, Durham, North Carolina, United States of America , Institute of Statistics and Decision Sciences, Duke University School of Medicine, Durham, North Carolina, United States of America , Department of Computer Science, Duke University, Durham, North Carolina, United States of America

Matt van de Rijn

Affiliation Department of Pathology, Stanford University School of Medicine, Palo Alto, California, United States of America

Marc J. van de Vijver

Affiliation Diagnostic Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Trevor Hastie

Affiliation Health Research and Policy, Stanford University School of Medicine, Palo Alto, California, United States of America

Patrick O Brown

To whom correspondence should be addressed. E-mail: pbrown@pmgm.stanford.edu

Affiliations Department of Biochemistry, Stanford University School of Medicine, Palo Alto, California, United States of America , Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, California, United States of America

Competing Interests

POB is a cofounder of the Public Library of Science and is on its board of directors.

Author Contributions

JTC, ZW, and POB conceived and designed the experiments. JTC, EHR, and ZW performed the experiments. JTC, ZW, DSAN, SM, MvdR, MJvdV, TH, and POB analyzed the data. DSAN, SM, MJvdV, and TH contributed reagents/materials/analysis tools. JTC, EHR, and POB wrote the paper.