About the Authors

Kornel E Schuebel

Contributed equally to this work with: Kornel E Schuebel, Wei Chen, Leslie Cope, Sabine C Glöckner

To whom correspondence should be addressed. E-mail: kornels@jhmi.edu (KES); sbaylin@jhmi.edu (SBB)

Affiliation Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America

Wei Chen

Contributed equally to this work with: Kornel E Schuebel, Wei Chen, Leslie Cope, Sabine C Glöckner

Affiliations Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America , Predoctoral Training Program in Human Genetics, The Johns Hopkins University, Baltimore, Maryland, United States of America

Leslie Cope

Contributed equally to this work with: Kornel E Schuebel, Wei Chen, Leslie Cope, Sabine C Glöckner

Affiliation Biometry and Clinical Trials Division, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America

Sabine C Glöckner

Contributed equally to this work with: Kornel E Schuebel, Wei Chen, Leslie Cope, Sabine C Glöckner

Affiliation Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Hiromu Suzuki

Affiliation First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan

Joo-Mi Yi

Affiliation Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America

Timothy A Chan

Affiliation Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America

Leander Van Neste

Affiliation Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium

Wim Van Criekinge

Affiliation Oncomethylome Sciences, Liege, Belgium

Sandra van den Bosch

Affiliation Department of Pathology, University of Maastricht, Maastricht, The Netherlands

Manon van Engeland

Affiliation Department of Pathology, University of Maastricht, Maastricht, The Netherlands

Angela H Ting

Affiliation Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America

Kamwing Jair

Affiliation Bionumerik Pharmaceuticals Inc., San Antonio, Texas, United States of America

Wayne Yu

Affiliation Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America

Minoru Toyota

Affiliation First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan

Kohzoh Imai

Affiliation First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan

Nita Ahuja

Affiliation Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

James G Herman

Affiliation Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America

Stephen B Baylin

To whom correspondence should be addressed. E-mail: kornels@jhmi.edu (KES); sbaylin@jhmi.edu (SBB)

Affiliations Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America , Predoctoral Training Program in Human Genetics, The Johns Hopkins University, Baltimore, Maryland, United States of America

Competing Interests

The commercial rights to the MSP technique belong to Oncomethylome Sciences. SBB and JGH serve as consultants to Oncomethylome Sciences and are entitled to royalties from any commercial use of this procedure.

Author Contributions

KES, WC, LC, SCG, HS, JMY, TAC, LVN, WVC, SvdB, MvE, AHT, KJ, MT, NA, and SBB conceived and designed the experiments. WC, LC, SCG, HS, JMY, TAC, LVN, WVC, SvdB, MvE, AHT, KJ, WY, MT, KI, NA, and JGH performed the experiments. KES, WC, LC, SCG, HS, JMY, TAC, LVN, WVC, SvdB, MvE, AHT, KJ, WY, MT, KI, NA, JGH, and SBB analyzed the data. KES, WC, LC, SCG, HS, JMY, TAC, LVN, WVC, SvdB, MvE, AHT, KJ, WY, MT, NA, and SBB contributed reagents/materials/analysis tools. KES and SBB wrote the paper.