Maintenance of Paternal Methylation and Repression of the Imprinted H19 Gene Requires MBD3

Kimberly J Reese; Shu Lin; Raluca I Verona; Richard M Schultz; Marisa S Bartolomei

doi:10.1371/journal.pgen.0030137

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Open Access

Peer-reviewed

Research Article

Maintenance of Paternal Methylation and Repression of the Imprinted H19 Gene Requires MBD3

Kimberly J Reese,

Affiliation Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Shu Lin,

Affiliation Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Raluca I Verona,

Affiliation Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Richard M Schultz,

Affiliation Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Marisa S Bartolomei

*To whom correspondence should be addressed. E-mail: bartolom@mail.med.upenn.edu

Affiliation Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

Maintenance of Paternal Methylation and Repression of the Imprinted H19 Gene Requires MBD3

Kimberly J Reese,
Shu Lin,
Raluca I Verona,
Richard M Schultz,
Marisa S Bartolomei

Published: August 17, 2007
https://doi.org/10.1371/journal.pgen.0030137

About the Authors

Kimberly J Reese

Affiliation Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Shu Lin

Affiliation Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Raluca I Verona

Affiliation Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Richard M Schultz

Affiliation Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Marisa S Bartolomei

*To whom correspondence should be addressed. E-mail: bartolom@mail.med.upenn.edu

Affiliation Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KJR, RMS, and MSB conceived and designed the experiments. KJR, RIV, and SL performed the experiments. KJR analyzed the data with input from SL, RIV, RMS, and MSB. KJR wrote the paper with editing and other suggestions from RMS and MSB.

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DNA methylation
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Blastocysts
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RNA interference
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Embryos
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Polymerase chain reaction
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Oocytes
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Beckwith-Wiedemann syndrome
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Genetic loci
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