Family-Based versus Unrelated Case-Control Designs for Genetic Associations

Evangelos Evangelou; Thomas A Trikalinos; Georgia Salanti; John P. A Ioannidis

doi:10.1371/journal.pgen.0020123

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Open Access

Peer-reviewed

Research Article

Family-Based versus Unrelated Case-Control Designs for Genetic Associations

Evangelos Evangelou,

Affiliation Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
⨯
Thomas A Trikalinos,

Affiliations Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece , Institute for Clinical Research and Health Policy Studies, Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Georgia Salanti,

Affiliation Biostatistics Unit, Medical Research Council, Cambridge, United Kingdom
⨯
John P. A Ioannidis

*To whom correspondence should be addressed. E-mail: jioannid@cc.uoi.gr

Affiliations Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece , Institute for Clinical Research and Health Policy Studies, Tufts University School of Medicine, Boston, Massachusetts, United States of America , Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece
⨯

Family-Based versus Unrelated Case-Control Designs for Genetic Associations

Evangelos Evangelou,
Thomas A Trikalinos,
Georgia Salanti,
John P. A Ioannidis

Published: August 11, 2006
https://doi.org/10.1371/journal.pgen.0020123

About the Authors

Evangelos Evangelou

Affiliation Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece

Thomas A Trikalinos

Affiliations Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece , Institute for Clinical Research and Health Policy Studies, Tufts University School of Medicine, Boston, Massachusetts, United States of America

Georgia Salanti

Affiliation Biostatistics Unit, Medical Research Council, Cambridge, United Kingdom

John P. A Ioannidis

*To whom correspondence should be addressed. E-mail: jioannid@cc.uoi.gr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

EE, TAT, GS, and JPAI conceived and designed the experiments. EE, TAT, GS, and JPAI analyzed the data. TAT and GS commented critically on the manuscript. EE and JPAI wrote the paper.

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