About the Authors

Beatriz Estrada

Contributed equally to this work with: Beatriz Estrada, Sung E Choe

Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America , Howard Hughes Medical Institute, Boston, Massachusetts, United States of America

Sung E Choe

Contributed equally to this work with: Beatriz Estrada, Sung E Choe

Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America , Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

Stephen S Gisselbrecht

Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America , Howard Hughes Medical Institute, Boston, Massachusetts, United States of America

Sebastien Michaud

Current address: Centre de Recherche du Centre Hospitalier de l'Université Laval (CRCHUL), Québec, Canada

Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America , Howard Hughes Medical Institute, Boston, Massachusetts, United States of America

Lakshmi Raj

Current address: Department of Dermatology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America , Howard Hughes Medical Institute, Boston, Massachusetts, United States of America

Brian W Busser

Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America , Howard Hughes Medical Institute, Boston, Massachusetts, United States of America

Marc S Halfon

Current address: Department of Biochemistry and Center of Excellence in Bioinformatics, State University of New York at Buffalo, Buffalo, New York, United States of America

Affiliation Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

George M Church

Affiliation Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

Alan M Michelson

To whom correspondence should be addressed. E-mail: michelson@receptor.med.harvard.edu

Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America , Howard Hughes Medical Institute, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

BE, SEC, MSH, and AMM conceived and designed the experiments. BE, SSG, SM, LR, and BWB performed the experiments. BE, SEC, SSG, SM, LR, BWB, and AMM analyzed the data. BE, SE, SSG, SM, LR, BWB, MSH, GMC, and AMM contributed reagents/materials/analysis tools. BE, SEC, and AMM wrote the paper.