TABLE S1: SP2 EXTENDED PATHWAY RANKINGS Rank KEGG pathway name pi^path Size Top 100 genes in pathway 1 Toll Like Receptor Signaling Pathway 0.254 766 TIRAP TLR2 RAC1 AKT1 IFNAR1 IFNAR2 CD80 IL12A IL12B PIK3R1 MAPK10 MAPK13 2 Jak Stat Signaling Pathway 0.179 1447 IL19 IL15RA PIAS2 PIAS1 CREBBP CBLB IL5RA AKT1 TPO IFNGR1 IFNAR1 IFNAR2 IL12A IL12B IL10RB PIK3R1 IL2RA PRLR 3 Ubiquitin Mediated Proteolysis 0.165 1603 CUL2 PIAS2 PIAS1 CBLB SMURF1 UBE2E2 RFWD2 NEDD4L UBE4B PARK2 4 Dilated Cardiomyopathy 0.103 3054 ADCY3 ADCY1 ADCY2 ADCY8 TGFB3 TGFB2 PRKACB CACNG3 RYR2 ITGA11 CACNB2 ITGB5 ITGB8 CACNA2D1 SLC8A1 ITGA1 ITGA2 CACNA2D3 CACNA1S LAMA2 ITGA9 ADCY9 CACNA1C 5 Cytokine Cytokine Receptor Interaction 0.100 2553 CX3CR1 PDGFRB IL1R1 IL5RA IL12A IL12B IL10RB IL19 TGFB3 TGFB2 IL15RA EGFR IL25 CSF1R CXCR5 TPO IFNGR1 IFNAR1 IFNAR2 IL2RA PRLR BMPR1B 6 Ecm Receptor Interaction 0.095 2271 SV2C ITGA11 ITGB5 ITGB8 COL4A4 COL4A2 COL4A1 ITGA1 ITGA2 LAMA2 LAMA1 VWF ITGA9 7 Arginine And Proline Metabolism 0.091 432 ALDH1B1 ALDH9A1 NOS1 8 Parkinsons Disease 0.090 1320 PARK2 9 Hypertrophic Cardiomyopathy Hcm 0.088 2819 TGFB3 TGFB2 CACNG3 RYR2 ITGA11 CACNB2 ITGB5 ITGB8 CACNA2D1 SLC8A1 ITGA1 ITGA2 CACNA2D3 CACNA1S LAMA2 ITGA9 CACNA1C 10 Small Cell Lung Cancer 0.068 1808 FHIT AKT1 RXRG PIAS2 PIAS1 PIK3R1 COL4A4 COL4A2 COL4A1 ITGA2 LAMA2 LAMA1 11 Natural Killer Cell Mediated Cytotoxicity 0.067 1781 HLA-C KRAS RAC1 VAV3 VAV2 PLCG2 IFNGR1 PRKCA IFNAR1 PRKCB IFNAR2 PPP3R1 NFATC2 PIK3R1 NFATC1 12 T Cell Receptor Signaling Pathway 0.065 1541 KRAS VAV3 VAV2 CBLB AKT1 PAK7 PPP3R1 NFATC2 PIK3R1 NFATC1 MAPK13 13 Tgf Beta Signaling Pathway 0.065 947 TGFB3 TGFB2 CREBBP SMURF1 BMPR1B 14 Olfactory Transduction 0.065 2497 PDE1C CALML3 ADCY3 PRKG1 PRKACB 15 Arrhythmogenic Right Ventricular Cardiomyopathy Arvc 0.063 3726 CACNG3 CTNNA3 CTNNA2 RYR2 ITGA11 CACNB2 ITGB5 TCF7L1 ITGB8 CACNA2D1 SLC8A1 ITGA1 ITGA2 CACNA2D3 CACNA1S LAMA2 ITGA9 CACNA1C 16 Ppar Signaling Pathway 0.062 758 RXRG 17 Taste Transduction 0.062 941 ADCY8 PRKACB PDE1A CACNA1B 18 Type I Diabetes Mellitus 0.060 776 HLA-C CD80 IL12A IL12B 19 Ribosome 0.057 261 20 Terpenoid Backbone Biosynthesis 0.056 147 21 Neuroactive Ligand Receptor Interaction 0.053 5745 GRIN3A PRLR 22 Regulation Of Actin Cytoskeleton 0.053 3803 PDGFRB ITGA11 KRAS RAC1 EGFR ITGB5 ITGB8 VAV3 ITGA1 ITGA2 VAV2 ITGA9 PAK7 PIK3R1 23 Mismatch Repair 0.053 222 24 Cell Adhesion Molecules Cams 0.053 3977 HLA-C ITGB8 ITGA9 CD80 25 Maturity Onset Diabetes Of The Young 0.053 239 26 Butanoate Metabolism 0.052 383 ALDH1B1 ALDH9A1 27 Purine Metabolism 0.052 3224 ADCY3 FHIT ADCY1 ADCY2 ADCY8 PDE1C PDE1A ADCY9 28 P53 Signaling Pathway 0.052 598 RFWD2 29 Dorso Ventral Axis Formation 0.050 581 KRAS EGFR 30 Basal Cell Carcinoma 0.049 589 TCF7L1 31 Metabolism Of Xenobiotics By Cytochrome P450 0.047 843 MGST3 32 Focal Adhesion 0.046 4581 PDGFRB ITGA11 RAC1 LAMA2 LAMA1 MAPK10 EGFR ITGB5 ITGB8 VAV3 ITGA1 ITGA2 VAV2 ITGA9 AKT1 PAK7 PRKCA PRKCB IGF1R PIK3R1 COL4A4 COL4A2 COL4A1 VWF 33 Drug Metabolism Cytochrome P450 0.045 878 MGST3 34 Glycosphingolipid Biosynthesis Globo Series 0.044 236 35 Thyroid Cancer 0.043 391 TCF7L1 KRAS RXRG 36 B Cell Receptor Signaling Pathway 0.043 1303 AKT1 PRKCB PPP3R1 KRAS RAC1 NFATC2 PIK3R1 NFATC1 VAV3 VAV2 PLCG2 37 Arachidonic Acid Metabolism 0.042 754 38 Rna Degradation 0.042 422 39 Viral Myocarditis 0.037 1117 HLA-C CD80 RAC1 LAMA2 40 Biosynthesis Of Unsaturated Fatty Acids 0.037 261 41 Limonene And Pinene Degradation 0.036 138 ALDH1B1 ALDH9A1 42 Spliceosome 0.036 676 43 Lysine Degradation 0.035 406 ALDH1B1 ALDH9A1 44 Base Excision Repair 0.035 275 45 Leishmania Infection 0.032 696 TLR2 TGFB3 TGFB2 IFNGR1 PRKCB IL12A IL12B MAPK13 46 Primary Immunodeficiency 0.032 295 47 Dna Replication 0.032 262 48 Axon Guidance 0.031 4198 KRAS RAC1 PAK7 PPP3R1 NFATC2 NFATC1 49 Melanogenesis 0.031 1835 ADCY3 ADCY1 ADCY2 ADCY8 PRKACB KRAS CREBBP PLCB4 PLCB1 PRKCA PRKCB TCF7L1 CALML3 ADCY9 50 Glycosphingolipid Biosynthesis Lacto And Neolacto Series 0.031 377