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Explore our new Craniofacial Genetics Collection

A curated selection of research from Guest Editors Seth Weinberg, Robert Cornell and Elizabeth Leslie

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08/13/2018

research article

Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales

Here, Simon Schäper and colleagues suggest that a 7TMR-DISM protein cooperates with a putative peptidoglycan-hydrolyzing protein, to facilitate unipolar cell wall formation and cell division in the Rhizobiales. The authors also find that 7TMR-DISM protein contributes to degradation of the second messenger c-di-GMP.

Image credit: Simon Schäper and colleagues

Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales

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Current Issue July 2018

08/15/2018

research article

The roles of SMYD4 in epigenetic regulation of cardiac development in zebrafish

In zebrafish, smyd4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart post-fertilization. Using a smyd4 mutant zebrafish line, Xiao, Wang, Hao and colleagues find that maternal and zygotic smyd4L544Efs*1 mutants demonstrate a strong defect in cardiomyocyte proliferation, leading to a severe cardiac malformation.

Image credit: Deyong Xiao, Huijun Wang, Lili Hao and colleagues

The roles of SMYD4 in epigenetic regulation of cardiac development in zebrafish

08/06/2018

research article

Baldspot/ELOVL6 is a conserved modifier of disease and the ER stress response 

Identifying and understanding how genetic variation impacts disease expression could improve diagnosis and treatment of patients. Here, Palu and Chow characterize a novel regulator of the ER stress response, the long chain fatty acid elongase Baldspot/ELOVL6. In the absence of this enzyme, cells undergoing ER stress display reduced cell death, and degeneration in a Drosophila disease model. 

Baldspot/ELOVL6 is a conserved modifier of disease and the ER stress response 

Image credit: Rebecca A. S. Palu and Clement Y. Chow

08/06/2018

research article

The transcription factor Dysfusion promotes fold and joint morphogenesis through regulation of Rho1

In this study, Córdoba and Estella use the formation of the fly leg joints as a model to study how Dysfusion (Dysf), a patterning transcription factor, regulates the cellular mechanisms that form the folds in the leg discs epithelium, and find that dysf modulates the localization and activity of Rho1 to drive cell apical constriction and epithelial folding in the leg disc.

The transcription factor Dysfusion promotes fold and joint morphogenesis through regulation of Rho1

Image credit: Sergio Córdoba and Carlos Estella

08/01/2018

research article

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

In this study, Howe et al investigate the shared genetic relationship between non-syndromic cleft lip/palate (nsCL/P) and facial morphology in a sample of around 6,000 Europeans from two different studies. They show that genetic risk factors for nsCL/P are associated with decreased philtrum width in unaffected individuals from the general population, and that the relationship is likely causal.

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

Image credit: Laurence J. Howe, Sarah J. Lewis and colleagues

07/19/2018

perspective

C. elegans germline cell death, live!

Morales and Greenstein comment on new work showing that physiological apoptosis targets at least two distinct populations of germ cells in C. elegans, and that the apoptosis machinery efficiently recognizes cells with two nuclei, from Raiders et al.

C. elegans germline cell death, live!

Image credit: Morales and Greenstein

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