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Katanin-like 2 (KATNAL2) functions in multiple aspects of haploid male germ cell development in the mouse

November 14, 2017

Katanin-like 2 (KATNAL2) functions in multiple aspects of haploid male germ cell development in the mouse

Image credit: Jessica E. M. Dunleavy and colleagues

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PLOS Research News

11/06/2017

research article

Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor

The oligodendrocyte density is greater and myelin sheaths are thicker in the adult male mouse brain when compared with females. In the present study, Charly Abi Ghanem and colleagues show that these sex differences emerge during the first 10 postnatal days, precisely at a stage when a late wave of oligodendrocyte progenitor cells arises and starts differentiating. 

Image credit: Charly Abi Ghanem and colleagues

Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor

Recently Published Articles

Current Issue

Current Issue October 2017

11/06/2017

research article

Hippo, TGF-β, and Src-MAPK pathways regulate transcription of the upd3 cytokine in Drosophila enterocytes upon bacterial infection

In Drosophila, the upstream events that stimulate the production of the primary cytokine Unpaired 3 (Upd3) in response to indigenous or pathogenic microbes have yet to be elucidated. In this study, Philip Houtz et al demonstrate that upd3 expression is driven in different cell types by separate microbe-responsive enhancers.

Image credit: Philip Houtz and colleagues

Hippo, TGF-β, and Src-MAPK pathways regulate transcription of the upd3 cytokine in Drosophila enterocytes upon bacterial infection

11/03/2017

research article

How convincing is a matching Y-chromosome profile?

Y-chromosome DNA profiles are important in forensic science, particularly when a male has been accused of assaulting a female. In this study, Mikkel M. Andersen and David Balding focus on approximating the number of males with matching Y profiles, rather than a population fraction or match probability. They describe a simulation model of Y profile evolution, implemented in open-source software, for approximating the number of males sharing a Y profile.

Image credit: Mikkel M. Andersen

How convincing is a matching Y-chromosome profile?

11/09/2017

research article

A subset of sweet-sensing neurons identified by IR56d are necessary and sufficient for fatty acid taste

In the present study, John M. Tauber et al identify a subset of sugar-sensing neurons in Drosophila that also responds to medium-chain FAs and are necessary and sufficient for behavioral response to FAs. Further, they find that despite being sensed by shared neuronal populations, flies can differentiate between the taste of sugar and FAs, fortifying the notion that FAs and sugar represent distinct taste modalities in flies.

A subset of sweet-sensing neurons identified by IR56d are necessary and sufficient for fatty acid taste

Image credit: John M. Tauber and colleagues

11/02/2017

research article

Co-option of the bZIP transcription factor Vrille as the activator of Doublesex1 in environmental sex determination of the crustacean Daphnia magna

In the sex determination process, an initial cue leads to sex-specific expression of the major effector of sexual differentiation, Doublesex (Dsx). In the present study, Nur Syafiqah Mohamad Ishak et al use the crustacean Daphnia magna for analyzing environmental sex determination.

Co-option of the bZIP transcription factor Vrille as the activator of Doublesex1 in environmental sex determination of the crustacean Daphnia magna

Image credit: Nur Syafiqah Mohamad Ishak and colleagues

10/30/2017

RESEARCH ARTICLE

AtHKT1 drives adaptation of Arabidopsis thaliana to salinity by reducing floral sodium content

Identifying the genetic variation driving plant adaptation to salinity is critical for understanding natural selection and evolutionary mechanisms. In this study, Dong An and colleagues reveal that the gene AtHKT1 drives natural variation in the adaptation of A. thaliana to salinity. Their evidence directly show that the AtHKT1 allele in the coastal accession Tsu-1 endows A. thaliana with enhanced adaptability to salinity. 

AtHKT1 drives adaptation of Arabidopsis thaliana to salinity by reducing floral sodium content

Image credit: Dong An and colleagues

10/19/2017

VIEWPOINTS

Guidelines for morpholino use in zebrafish

Didier Y. R. Stainier and colleagues provide an updated set of guidelines regarding the use of MOs in zebrafish that they anticipate will be of value for experimentalists as well as journal and grant reviewers, and decision makers. 

Guidelines for morpholino use in zebrafish

Image credit: NICHD, Flickr, CC BY

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