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Interaction fingerprint of hyaluronan and its CD44 receptor

The ubiquitous hyaluronan sugar binds to its native CD44 receptor, mediating cell-environment interactions. Hyaluronan can bind CD44 in three well-defined binding modes, each characterized by a pair of spatially separated arginine residues. The image shows one of the binding modes discovered using simulation techniques. Each mode might play a different functional role, e.g. in aggregation kinetics.Vuorio et al.

Image Credit: Vuorio et al.