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August 2013

The probability of coexistence correlates with the degree of niche segregation on the monomers as resources. Each cell is an average of numerical results over 1,000 random parameter setups. Purple indicates highly improbable coexistence and green indicates likely coexistence. Sequences are arranged along the axes first according to Hamming distance and secondly according to lexicographic ordering (increasing B content towards bottom and right). See Szilágyi et al.

Image Credit: András Szilágyi, István Zachar, and Eörs Szathmáry (Parmenides Center for the Conceptual Foundations of Science, Pullach, Germany)

Message from ISCB

International Society for Computational Biology Welcomes Its Newest Class of Fellows

Christiana N. Fogg, Diane E. Kovats

Research Articles

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A General Model for Toxin-Antitoxin Module Dynamics Can Explain Persister Cell Formation in E. coli

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Visual Nonclassical Receptive Field Effects Emerge from Sparse Coding in a Dynamical System

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Flux Imbalance Analysis and the Sensitivity of Cellular Growth to Changes in Metabolite Pools

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The Individualized Genetic Barrier Predicts Treatment Response in a Large Cohort of HIV-1 Infected Patients

Niko Beerenwinkel, Hesam Montazeri, Heike Schuhmacher, Patrick Knupfer, Viktor von Wyl, Hansjakob Furrer, Manuel Battegay, Bernard Hirschel, Matthias Cavassini, Pietro Vernazza, Enos Bernasconi, Sabine Yerly, Jürg Böni, Thomas Klimkait, Cristina Cellerai, Huldrych F. Günthard, The Swiss HIV Cohort Study

Network and Atomistic Simulations Unveil the Structural Determinants of Mutations Linked to Retinal Diseases

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How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation

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Stochasticity, Bistability and the Wisdom of Crowds: A Model for Associative Learning in Genetic Regulatory Networks

Matan Sorek, Nathalie Q. Balaban, Yonatan Loewenstein

A Self-Directed Method for Cell-Type Identification and Separation of Gene Expression Microarrays

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