Dynamic, biped walking is a difficult motor coordination problem for robots. "RunBot," shown here, contains two joint motors and two hip motors and an upper-body component. These actuators are dynamically controlled by a neural network that can adapt via simulated synaptic plasticity to novel situations, such as a change in the terrain. This way, RunBot's walking pattern looks rather human-like (see Video S2 5.1 MPG), and the little machine successfully tackles difficult walking situations (see Manoonpong et al, e134).
Education
Introduction to Computational Proteomics
PLOS Computational Biology: published July 27, 2007 | https://doi.org/10.1371/journal.pcbi.0030114
Review
Quantitative Analysis of Cell Nucleus Organisation
PLOS Computational Biology: published July 27, 2007 | https://doi.org/10.1371/journal.pcbi.0030138
Research Articles
Key Role of Local Regulation in Chemosensing Revealed by a New Molecular Interaction-Based Modeling Method
PLOS Computational Biology: published July 21, 2006 | https://doi.org/10.1371/journal.pcbi.0020082
Sarcomere Lattice Geometry Influences Cooperative Myosin Binding in Muscle
PLOS Computational Biology: published July 13, 2007 | https://doi.org/10.1371/journal.pcbi.0030115
Not All Scale-Free Networks Are Born Equal: The Role of the Seed Graph in PPI Network Evolution
PLOS Computational Biology: published July 6, 2007 | https://doi.org/10.1371/journal.pcbi.0030118
Protein–Protein Interaction Hotspots Carved into Sequences
PLOS Computational Biology: published July 13, 2007 | https://doi.org/10.1371/journal.pcbi.0030119
Evolution of Function in the “Two Dinucleotide Binding Domains” Flavoproteins
PLOS Computational Biology: published July 20, 2007 | https://doi.org/10.1371/journal.pcbi.0030121
Efficiency, Selectivity, and Robustness of Nucleocytoplasmic Transport
PLOS Computational Biology: published July 13, 2007 | https://doi.org/10.1371/journal.pcbi.0030125
A Computational Pipeline for High- Throughput Discovery of cis-Regulatory Noncoding RNA in Prokaryotes
PLOS Computational Biology: published July 6, 2007 | https://doi.org/10.1371/journal.pcbi.0030126
Sensitivity Analysis of Intracellular Signaling Pathway Kinetics Predicts Targets for Stem Cell Fate Control
PLOS Computational Biology: published July 6, 2007 | https://doi.org/10.1371/journal.pcbi.0030130
Global and Local Architecture of the Mammalian microRNA–Transcription Factor Regulatory Network
PLOS Computational Biology: published July 13, 2007 | https://doi.org/10.1371/journal.pcbi.0030131
Novel Algorithms Reveal Streptococcal Transcriptomes and Clues about Undefined Genes
PLOS Computational Biology: published July 6, 2007 | https://doi.org/10.1371/journal.pcbi.0030132
Optimal Timing and Duration of Induction Therapy for HIV-1 Infection
PLOS Computational Biology: published July 13, 2007 | https://doi.org/10.1371/journal.pcbi.0030133
Adaptive, Fast Walking in a Biped Robot under Neuronal Control and Learning
PLOS Computational Biology: published July 13, 2007 | https://doi.org/10.1371/journal.pcbi.0030134
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Evolutionary History of Mammalian Transposons Determined by Genome-Wide Defragmentation
PLOS Computational Biology: published July 13, 2007 | https://doi.org/10.1371/journal.pcbi.0030137
A First-Principles Model of Early Evolution: Emergence of Gene Families, Species, and Preferred Protein Folds
PLOS Computational Biology: published July 13, 2007 | https://doi.org/10.1371/journal.pcbi.0030139
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PLOS Computational Biology: published July 20, 2007 | https://doi.org/10.1371/journal.pcbi.0030140
Computationally Derived Points of Fragility of a Human Cascade Are Consistent with Current Therapeutic Strategies
PLOS Computational Biology: published July 20, 2007 | https://doi.org/10.1371/journal.pcbi.0030142
Prediction of Gene Expression in Embryonic Structures of Drosophila melanogaster
PLOS Computational Biology: published July 20, 2007 | https://doi.org/10.1371/journal.pcbi.0030144
Detecting Emerging Transmissibility of Avian Influenza Virus in Human Households
PLOS Computational Biology: published July 27, 2007 | https://doi.org/10.1371/journal.pcbi.0030145
Chemotaxis Receptor Complexes: From Signaling to Assembly
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Corrections
Correction: Computational Model Explains High Activity and Rapid Cycling of Rho GTPases within Protein Complexes
PLOS Computational Biology: published July 27, 2007 | https://doi.org/10.1371/journal.pcbi.0030136
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Correction: In Search of the Biological Significance of Modular Structures in Protein Networks
PLOS Computational Biology: published July 27, 2007 | https://doi.org/10.1371/journal.pcbi.0030146
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Retraction
Retraction: Measures of Clade Confidence Do Not Correlate with Accuracy of Phylogenetic Trees
PLOS Computational Biology: published July 20, 2007 | https://doi.org/10.1371/journal.pcbi.0030158