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Table of Contents: September 2011

During development a cellular population, the so-called "organizer," ensures segregation of the cells that lead to the dorsal (D) and ventral (V) parts of the wing blade of Drosophila. In Canela-Xandri et al. (10.1371/journal.pcbi.1002153), the authors shed light on the mechanical and dynamical properties of cells necessary to perform such a task robustly as cells grow and proliferate. The study also unveils how the organizer is conveniently scaled as the wing tissue grows. The image artistically depicts a snapshot of the study's simulations: dorsal and ventral cells at the wing compartments bulk (white), organizer cells (red), and the so-called DV boundary (green line). In this study the authors used a dynamical vertex model that accounts for the forces acting on cells and that includes the modeling of the cell cycle duration and cleavage with stochastic variability. In summary, the paper presents a theoretical and computational approach for understanding, in a quantitative and predictive manner, the dynamics, structure, and stability of the DV organizer.

Image Credit: Javier Buceta, Computer Simulation and Modeling (Co.S.Mo.) Lab, Parc Cientific de Barcelona, Spain.

Editorials

Ten Simple Rules for Getting Help from Online Scientific Communities

Giovanni M. Dall'Olio, Jacopo Marino, Michael Schubert, Kevin L. Keys, Melanie I. Stefan, Colin S. Gillespie, Pierre Poulain, Khader Shameer, Robert Sugar, Brandon M. Invergo, Lars J. Jensen, Jaume Bertranpetit, Hafid Laayouni

Reviews

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Research Articles

Dynamics and Mechanical Stability of the Developing Dorsoventral Organizer of the Wing Imaginal Disc

Oriol Canela-Xandri, Francesc Sagués, Jaume Casademunt, Javier Buceta

A Mathematical Model of Muscle Containing Heterogeneous Half-Sarcomeres Exhibits Residual Force Enhancement

Stuart G. Campbell, P. Chris Hatfield, Kenneth S. Campbell

A Model for the Origin and Properties of Flicker-Induced Geometric Phosphenes

Michael Rule, Matthew Stoffregen, Bard Ermentrout

A Multi-Compartment Model for Interneurons in the Dorsal Lateral Geniculate Nucleus

Geir Halnes, Sigita Augustinaite, Paul Heggelund, Gaute T. Einevoll, Michele Migliore

Monkeys and Humans Share a Common Computation for Face/Voice Integration

Chandramouli Chandrasekaran, Luis Lemus, Andrea Trubanova, Matthias Gondan, Asif A. Ghazanfar

Long-Range Intra-Protein Communication Can Be Transmitted by Correlated Side-Chain Fluctuations Alone

Kateri H. DuBay, Jacques P. Bothma, Phillip L. Geissler

LsrR Quorum Sensing “Switch” Is Revealed by a Bottom-Up Approach

Sara Hooshangi, William E. Bentley

The Effect of Heterogeneity on Invasion in Spatial Epidemics: From Theory to Experimental Evidence in a Model System

Franco M. Neri, Anne Bates, Winnie S. Füchtbauer, Francisco J. Pérez-Reche, Sergei N. Taraskin, Wilfred Otten, Douglas J. Bailey, Christopher A. Gilligan

Smart Swarms of Bacteria-Inspired Agents with Performance Adaptable Interactions

Adi Shklarsh, Gil Ariel, Elad Schneidman, Eshel Ben-Jacob

Protein Networks as Logic Functions in Development and Cancer

Janusz Dutkowski, Trey Ideker

A Single-Rate Context-Dependent Learning Process Underlies Rapid Adaptation to Familiar Object Dynamics

James N. Ingram, Ian S. Howard, J. Randall Flanagan, Daniel M. Wolpert

Time Scale Hierarchies in the Functional Organization of Complex Behaviors

Dionysios Perdikis, Raoul Huys, Viktor K. Jirsa

Why Don't CD8+ T Cells Reduce the Lifespan of SIV-Infected Cells In Vivo?

Marjet Elemans, Nafisa-Katrin Seich al Basatena, Nichole R. Klatt, Christos Gkekas, Guido Silvestri, Becca Asquith

Determinants of the Spatiotemporal Dynamics of the 2009 H1N1 Pandemic in Europe: Implications for Real-Time Modelling

Stefano Merler, Marco Ajelli, Andrea Pugliese, Neil M. Ferguson

An Integrated Disease/Pharmacokinetic/Pharmacodynamic Model Suggests Improved Interleukin-21 Regimens Validated Prospectively for Mouse Solid Cancers

Moran Elishmereni, Yuri Kheifetz, Henrik Søndergaard, Rune Viig Overgaard, Zvia Agur

Filament Depolymerization Can Explain Chromosome Pulling during Bacterial Mitosis

Edward J. Banigan, Michael A. Gelbart, Zemer Gitai, Ned S. Wingreen, Andrea J. Liu

Neuromotor Noise, Error Tolerance and Velocity-Dependent Costs in Skilled Performance

Dagmar Sternad, Masaki O. Abe, Xiaogang Hu, Hermann Müller

Network-Based Prediction and Analysis of HIV Dependency Factors

T. M. Murali, Matthew D. Dyer, David Badger, Brett M. Tyler, Michael G. Katze

Signalling and the Evolution of Cooperative Foraging in Dynamic Environments

Colin J. Torney, Andrew Berdahl, Iain D. Couzin

Retracing Micro-Epidemics of Chagas Disease Using Epicenter Regression

Michael Z. Levy, Dylan S. Small, Daril A. Vilhena, Natalie M. Bowman, Vivian Kawai, Juan G. Cornejo del Carpio, Eleazar Cordova-Benzaquen, Robert H. Gilman, Caryn Bern, Joshua B. Plotkin

Binding Leverage as a Molecular Basis for Allosteric Regulation

Simon Mitternacht, Igor N. Berezovsky

A Detailed History of Intron-rich Eukaryotic Ancestors Inferred from a Global Survey of 100 Complete Genomes

Miklos Csuros, Igor B. Rogozin, Eugene V. Koonin

A Switching Mechanism in Doxorubicin Bioactivation Can Be Exploited to Control Doxorubicin Toxicity

Nnenna A. Finn, Harry W. Findley, Melissa L. Kemp

Integrating Quantitative Knowledge into a Qualitative Gene Regulatory Network

Jérémie Bourdon, Damien Eveillard, Anne Siegel

Structured Pathway across the Transition State for Peptide Folding Revealed by Molecular Dynamics Simulations

Lipi Thukral, Isabella Daidone, Jeremy C. Smith

A Combined Experimental and Mathematical Approach for Molecular-based Optimization of Irinotecan Circadian Delivery

Annabelle Ballesta, Sandrine Dulong, Chadi Abbara, Boris Cohen, Alper Okyar, Jean Clairambault, Francis Levi

Efficacy of Synaptic Inhibition Depends on Multiple, Dynamically Interacting Mechanisms Implicated in Chloride Homeostasis

Nicolas Doyon, Steven A. Prescott, Annie Castonguay, Antoine G. Godin, Helmut Kröger, Yves De Koninck

Genome-Scale Analysis of Translation Elongation with a Ribosome Flow Model

Shlomi Reuveni, Isaac Meilijson, Martin Kupiec, Eytan Ruppin, Tamir Tuller

A Systems Biology Approach Identifies Molecular Networks Defining Skeletal Muscle Abnormalities in Chronic Obstructive Pulmonary Disease

Nil Turan, Susana Kalko, Anna Stincone, Kim Clarke, Ayesha Sabah, Katherine Howlett, S. John Curnow, Diego A. Rodriguez, Marta Cascante, Laura O'Neill, Stuart Egginton, Josep Roca, Francesco Falciani

A Computational Approach to Finding Novel Targets for Existing Drugs

Yvonne Y. Li, Jianghong An, Steven J. M. Jones