Table of Contents: February 2011

Small-scale genetic interactions have been used for decades to unravel biological pathways. In recent years, experimental techniques have been developed to map them at the genome level, providing large-scale genetic interaction networks. In particular, in budding yeast the genetic network mapped by Synthetic Genetic Array was revealed as both a powerful tool to identify functional modules in the cell and a tremendous resource ready for more exploration. This image shows a view of this genetic interaction network visualized with BioLayoutExpress3D. Patterns in the genetic network can help understand the organization of biological processes (see Michaut, et al. doi:10.1371/journal.pcbi.1001092).

Image Credit: Magali Michaut, University of Toronto

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Digital Atlasing and Standardization in the Mouse Brain

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