Table of Contents: November 2007

A trinucleotide disease is like a genetic time bomb. A patient with such a disease inherits a DNA region consisting of a three-letter code repeated abnormally many times. The age at which the disease strikes the patient is encoded by the number of repeats. A universal mechanism by which this molecular time bomb operates in this broad family of hereditary diseases has been suggested (see Kaplan et al, e235).

Image Credit: Genia Brodsky, Weizmann Institute of Science


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