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Table of Contents: November 2005

Shown here is a symmetric model of tetrameric acetylcholinesterase assembled with collagen Q tail (yellow in the middle). The peripheral anionic site residues are shown as cyan, and the catalytic residue serine 203 is shown as green balls (see Zhang and McCammon).

Image Credit: Image created by David Zhang using VMD v1.8.4.

Message from ISCB

Bioinformatics Education—Perspectives and Challenges

Shoba Ranganathan

Perspective

NIH Roadmap Interdisciplinary Research Initiatives

Michael F Huerta, Gregory K Farber, Elizabeth L Wilder, Dushanka V Kleinman, Patricia A Grady, David A Schwartz, Lawrence A Tabak

Review

Quasispecies Made Simple

J. J Bull, Lauren Ancel Meyers, Michael Lachmann

Research Articles

Genomic Variability within an Organism Exposes Its Cell Lineage Tree

Dan Frumkin, Adam Wasserstrom, Shai Kaplan, Uriel Feige, Ehud Shapiro

Use of Artificial Genomes in Assessing Methods for Atypical Gene Detection

Rajeev K Azad, Jeffrey G Lawrence

A Guild of 45 CRISPR-Associated (Cas) Protein Families and Multiple CRISPR/Cas Subtypes Exist in Prokaryotic Genomes

Daniel H Haft, Jeremy Selengut, Emmanuel F Mongodin, Karen E Nelson

Stealth Proteins: In Silico Identification of a Novel Protein Family Rendering Bacterial Pathogens Invisible to Host Immune Defense

Peter Sperisen, Christoph D Schmid, Philipp Bucher, Olav Zilian

Quantitative Analysis of Genetic and Neuronal Multi-Perturbation Experiments

Alon Kaufman, Alon Keinan, Isaac Meilijson, Martin Kupiec, Eytan Ruppin

Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis

Thomas LaFramboise, Barbara A Weir, Xiaojun Zhao, Rameen Beroukhim, Cheng Li, David Harrington, William R Sellers, Matthew Meyerson

Refining Protein Subcellular Localization

Michelle S Scott, Sara J Calafell, David Y Thomas, Michael T Hallett