Figures
Models capturing multi-regional spiking in neocortical layer 5 pyramidal neurons.
Neocortical L5 pyramidal cells generate dendritic Ca2+ spikes in distal apical region (top red region and corresponding voltage trace) as well as Na+ spikes in perisomatic region (bottom red region and voltage trace). The two spiking zones interact electrically in a complex "ping-pong"-like manner. This study provides detailed conductance-based models that faithfully replicate these important spiking properties together with their variability, as measured experimentally. This was achieved using multi-objective evolutionary optimization algorithm and experimentally measured statistics of both Ca2+ and Na+ spiking features. The study highlights the candidate key biophysical mechanisms underlying these active electrical properties of L5 pyramidal cells. (see Hay et al., doi:10.1371/journal.pcbi.1002107).
Image Credit: Ariel Chai, Brisbane, Australia
Citation: (2011) PLoS Computational Biology Issue Image | Vol. 7(7) July 2011. PLoS Comput Biol 7(7): ev07.i07. https://doi.org/10.1371/image.pcbi.v07.i07
Published: July 28, 2011
Copyright: © 2011 Chai. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Neocortical L5 pyramidal cells generate dendritic Ca2+ spikes in distal apical region (top red region and corresponding voltage trace) as well as Na+ spikes in perisomatic region (bottom red region and voltage trace). The two spiking zones interact electrically in a complex "ping-pong"-like manner. This study provides detailed conductance-based models that faithfully replicate these important spiking properties together with their variability, as measured experimentally. This was achieved using multi-objective evolutionary optimization algorithm and experimentally measured statistics of both Ca2+ and Na+ spiking features. The study highlights the candidate key biophysical mechanisms underlying these active electrical properties of L5 pyramidal cells.(see Hay et al., doi:10.1371/journal.pcbi.1002107).
Image Credit: Ariel Chai, Brisbane, Australia