Figures
From cell division to tissue network topology.
Cell division is a key mechanism in morphogenesis, yet the relationship between local cell division and global tissue architecture (e.g., the distribution of cell shapes) remains poorly understood. In this study (Nagpal et al., doi:10.1371/journal.pcbi.1000412), the authors present a computational framework for studying the topological networks that are created by proliferative cell division (image). This framework reveals how different cell division mechanisms create strikingly different "signature" tissue statistics, which can be used to infer necessary division properties. The model also suggests that while nearly identical cell shape distributions have been observed in proliferating plant and fruitfly epithelia, they achieve this by distinct cell division mechanisms.
Image Credit: Ankit Patel, Radhika Nagpal (Harvard University).
Citation: (2009) PLoS Computational Biology Issue Image | Vol. 5(6) June 2009. PLoS Comput Biol 5(6): ev05.i06. https://doi.org/10.1371/image.pcbi.v05.i06
Published: June 26, 2009
Copyright: © 2009 Nagpal, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Cell division is a key mechanism in morphogenesis, yet the relationship between local cell division and global tissue architecture (e.g., the distribution of cell shapes) remains poorly understood. In this study (Nagpal et al., doi:10.1371/journal.pcbi.1000412), the authors present a computational framework for studying the topological networks that are created by proliferative cell division (image). This framework reveals how different cell division mechanisms create strikingly different "signature" tissue statistics, which can be used to infer necessary division properties. The model also suggests that while nearly identical cell shape distributions have been observed in proliferating plant and fruitfly epithelia, they achieve this by distinct cell division mechanisms.
Image Credit: Ankit Patel, Radhika Nagpal (Harvard University).