Figures
Biology of the microtubule-associated protein tau.
The phosphoprotein tau is normally bound to microtubules. However, tau that is abnormally phosphorylated dissociates from microtubules. Accumulated soluble tau molecules then misfold and aggregate. These aggregations are a hallmark of the tauopathies responsible for cognitive dysfunction and neuropathies such as Alzheimer's disease (see Yuraszeck et al. doi:10.1371/journal.pcbi.1000997).
Image Credit: Peter Allen
Citation: (2010) PLoS Computational Biology Issue Image | Vol. 6(11) November 2010. PLoS Comput Biol 6(11): ev06.i11. https://doi.org/10.1371/image.pcbi.v06.i11
Published: November 24, 2010
Copyright: © 2010 Yuraszeck et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The phosphoprotein tau is normally bound to microtubules. However, tau that is abnormally phosphorylated dissociates from microtubules. Accumulated soluble tau molecules then misfold and aggregate. These aggregations are a hallmark of the tauopathies responsible for cognitive dysfunction and neuropathies such as Alzheimer's disease (see Yuraszeck et al. doi:10.1371/journal.pcbi.1000997).
Image Credit: Peter Allen